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Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced

  • US 20040067582A1
  • Filed: 10/28/2003
  • Published: 04/08/2004
  • Est. Priority Date: 09/12/2000
  • Status: Active Grant
First Claim
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1. A process for preparing a devitalized soft tissue graft for implantation into a mammalian system, comprising:

  • extracting a soft tissue sample with an extracting solution comprising one or more non-denaturing detergents, to produce an extracted tissue;

    washing said extracted tissue with water which is passed through a bed of hydrophobic adsorbent resin and anion exchange resin and subsequently inducing a pressure mediated flow of storage or decontaminating solution comprising one or more decontaminating agents and water replacement agents, through said extracted tissue, to produce said devitalized soft tissue graft; and

    storing said tissue in said solution;

    wherein said devitalized soft tissue graft retains non-viable cells and/or cellular elements capable of inducing graft repopulation with the appropriate cell type.

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