Method for stimulating hair growth and kit for carrying out said method
First Claim
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1. A method of creating new hair follicles in the skin of a human subject, the skin comprising dermal and epidermal layers, the method comprising the steps of:
- injecting, atraumatically, an aliquot of cultured follicle progenitor cell clusters into a vesicle defined by the dermal and epidermal layers of the skin of the subject and, permitting the cells to grow to produce new hair follicles.
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Abstract
Methods and devices are disclosed for use in the treatment of male pattern baldness and other conditions involving hair loss by facilitating the growth of new hair in the dermis of a living subject. The method involves the steps of atraumatically injecting follicle progenitor cells into the interface between the dermis and the epidermis and allowing the cells to grow into new hair follicles.
121 Citations
20 Claims
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1. A method of creating new hair follicles in the skin of a human subject, the skin comprising dermal and epidermal layers, the method comprising the steps of:
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injecting, atraumatically, an aliquot of cultured follicle progenitor cell clusters into a vesicle defined by the dermal and epidermal layers of the skin of the subject and, permitting the cells to grow to produce new hair follicles.
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2. A method of creating new hair follicles in a human subject, comprising:
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a) providing follicle progenitor cells derived from biopsied hair follicles;
b) culturing the progenitor cells by allowing them to increase their number;
c) forming the cultured cells into cell clusters;
d) creating a bleb at the interface between the dermis and epidermis of the skin at a site where one or more new hair follicles are desired;
e) injecting an aliquot of the cell clusters into the bleb; and
f) permitting the cells to grow to produce new hair follicles. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 13)
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- 12. A device for the injection of cultured follicle progenitor cells comprising a hypodermic needle, a plug of cultured follicle progenitor cells contained in the lumen at the tip of the hypodermic needle, and a means for ejecting said plug of cells after injecting said needle into the skin.
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15. A method of creating new hair follicles in a human subject, comprising:
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a) providing follicle progenitor cells derived from biopsied hair follicles;
b) culturing the progenitor cells by allowing them to increase their number;
c) forming the cultured cells into cell clusters;
d) combining the cell clusters with a structure-forming excipient;
e) creating a bleb, atraumatically, at the interface between the dermis and epidermis of the skin adjacent a site where one or more new hair follicles are desired;
f) injecting an aliquot of the cell clusters into the bleb; and
g) permitting the cells to grow to produce new hair follicles. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification