Packaged antimicrobial medical device and method of preparing same
First Claim
1. An antimicrobial suture assembly comprising:
- a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and
a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture.
1 Assignment
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Accused Products
Abstract
An antimicrobial suture assembly comprising a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture; and a method for making.
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Citations
26 Claims
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1. An antimicrobial suture assembly comprising:
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a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and
a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 25)
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10. A packaged suture having antimicrobial properties comprising:
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an outer package comprising an inner surface having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said package; and
a suture assembly comprising;
a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and
a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture.
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11. An antimicrobial suture assembly comprising:
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a containment compartment comprising one or more surfaces having between about 5 ppm and 5000 ppm of 2,4,4′
-trichloro-2′
-hydroxydiphenyl ether disposed thereon, to substantially inhibit bacterial colonization on said containment compartment; and
an elongate braided structure formed from a plurality of filaments of a polymeric material comprising greater than about 70% polymerized glycolide suture positioned within the containment compartment, said elongate braided suture comprising one or more surfaces having a coating material disposed thereon, said coating comprising a film forming absorbable polymer, a substantially water-insoluble salt of a fatty acid and between about 30 ppm and 5000 ppm of 2,4,4′
-trichloro-2′
-hydroxydiphenyl ether for substantially inhibiting microbial growth on or adjacent said braided suture when said suture is implanted in a patient.
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12. A packaged antimicrobial suture produced according to the process of:
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providing a containment compartment that is substantially free of an antimicrobial agent;
positioning a suture within the containment compartment, said suture comprising one or more surfaces having a preselected amount antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof;
placing the containment compartment having the suture in a package; and
subjecting the package to temperature and pressure conditions sufficient to vapor transfer a first portion of an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of a second portion of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
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13. A method of making a packaged antimicrobial suture comprising the steps of:
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providing a containment compartment that is substantially free of an antimicrobial agent;
positioning a suture within the containment compartment, said suture comprising one or positioning a suture within the containment compartment, said suture comprising one or more surfaces having a preselected amount of an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof;
placing the containment compartment having the suture therein in an outer package having an inner surface; and
subjecting the outer package to temperature and pressure conditions sufficient to vapor transfer an effective amount as a first portion of the antimicrobial agent from the suture to the containment compartment and the inner surface, while retaining an effective amount of a second portion of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture, the inner surface of the package and the containment compartment. - View Dependent Claims (14, 15, 16, 17)
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18. A packaged medical device having antimicrobial properties, comprising:
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at least one hermetically sealed package comprising an inner surface having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said package; and
at least one implantable medical device positioned within said at least one hermetically sealed package, said medical device comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said medical device. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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26. A packaged medical device having antimicrobial properties, comprising:
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at least one package comprising an inner surface having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said package; and
at least one implantable medical device positioned within said at least one package, said medical device being selected from the group consisting of sutures, surgical meshes, hernia plugs, brachy seed spacers, suture clips, suture anchors, adhesion prevention meshes and films, and suture knot clips; and
said medical device comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said medical device.
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Specification