Active fluid delivery catheter

• US 20040068299A1
• Filed: 10/02/2002
• Published: 04/08/2004
• Est. Priority Date: 10/02/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sommer, John L., Laske, Timothy G., Sigg, Daniel C.
• Granted Patent: US 7,103,418 B2
• Time in Patent Office: Days
• US Class Current: 607/3
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 2025/0095 being one or more needles protruding from the distal tip and which are not used for injection nor for electro-stimulation, e.g. for fixation purposes
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0575 with drug delivery
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium

Abstract

A medical system incorporating fluid delivery and lead delivery lumens dispense fluid into a volume of tissue. The fluid comprises or contains a pharmacologic, genetic, or biologic agent. The fluid may be dispensed initially during implantation or later using a minimally invasive medical procedure. A hollow tissue-piercing tip portion provides fluid delivery to the volume of tissue at one or more targeted sites. A medical electrical lead may be chronically implanted at the treated tissue site. The system includes a guide catheter having a fluid delivery lumen in communication with an active fixation, fluid dispensing member and a lead delivery lumen for deploying a medical lead. The system includes a medical lead having an active or passive fixation member and a central lumen through which a tip portion is deployed. The system may be used with implantable pulse generators, drug delivery pumps and the like.

Claims

1. An implantable fluid delivery system, comprising:

an elongated guide catheter having at least one elongated fluid delivery lumen disposed therein; and

a hollow, perforated active fixation tip member in fluid communication with said at least one fluid delivery lumen.

2. A system according to claim 1, further comprising at least one lead-delivery lumen disposed within said elongated guide catheter.

3. A system according to claim 2, further comprising a medical electrical lead disposed within said at least one lead-delivery lumen.

4. A system according to claim 3, wherein said medical electrical lead further comprises an electrical conductor disposed within a lead body portion and said electrical conductor is electrically coupled to an electrode structure in contact with tissue and said electrically conductor electrically couples to a one of the following:

an implantable pulse generator, a positive pressure drug pump, a negative pressure drug pump, a micro-osmotic pump, a positive displacement pump, a solenoid-activated pump, a neurostimulator, a pacemaker, an ICD.

5. A system according to claim 4, wherein said tissue is at least a portion of one of the following types of tissue:

a cardiac tissue, a nerve tissue, a muscle tissue, an organ tissue, a central nervous system tissue, a brain tissue.

6. A system according to claim 4, wherein the electrode structure is at least a one of the following:

a ring electrode, a tip electrode, a defibrillation electrode, a spherical electrode, a hemispherical electrode, an electrophysiological mapping electrode, an electrogram electrode, an ECG electrode, a subcutaneous electrode, a helical electrode, a hollow needle electrode, a stake electrode, a tine electrode, a fish-hook electrode.

7. A system according to claim 1, wherein the active fixation tip member comprises at least a one of the following:

a helical electrode, a hollow needle electrode, a stake electrode, a tine electrode, a fish-hook electrode.

8. A system according to claim 1, wherein a proximal end of said guide-catheter is sealed and disposed proximate a portion of epidermis of a patient.

9. A system according to claim 7, wherein said active fixation tip member is disposed recessed from the distal end of the guide-catheter and is manually deployable therefrom and manually retractable back into said recessed location.

10. A system according to claim 2, wherein said guide-catheter further comprises a steerable catheter and said steerable catheter comprises a manually adjustable handle means mechanically coupled to a proximal end of the guide-catheter for providing torque to the proximal portion of said guide-catheter.

11. A system according to claim 10, wherein said handle means mechanically couples to a proximal portion of at least one pull wire and wherein said at least one pull wire is mechanically coupled to a distal portion of said guide-catheter.

12. A system according to claim 11, further comprising a fluid reservoir fluidly coupled to a delivery port of said handle means and wherein said delivery port is in fluid communication with said at least one fluid delivery lumen.

13. A system according to claim 12, wherein a fluid is pre-filled into said fluid reservoir, said fluid comprising a pharmacological agent, a genetic agent, or a biological agent.

14. A system according to claim 13, further comprising a fluid stability-enhancing or fluid delivery vehicle combined with the fluid.

15. A method for guiding an irrigated active fixation means to a portion of tissue, piercing said portion of tissue and dispensing a fluid therein, comprising:

advancing a guide-catheter to a portion of tissue, wherein said guide catheter has at least one fluid delivery lumen disposed therein;

piercing said portion of tissue with an irrigated tip portion of said guide-catheter, wherein said guide-catheter is fluidly coupled to the at least one fluid delivery lumen; and

dispensing a fluid into said pierced portion of tissue through said fluid delivery lumen and said irrigated tip portion.

16. A method according to claim 15, wherein said fluid is a pharmacological agent, a genetic agent, or a biological agent.

17. A method according to claim 16, further comprising:

reversing said irrigated tip portion from an original insertion depth and again dispensing the fluid.

18. A method according to claim 16, wherein said dispensing is a single-shot bolus delivery.

19. A method according to claim 16, further comprising retracting said irrigated tip portion into a distal portion of said guide catheter.

20. A method according to claim 19, further comprising:

delivering a medical electrical lead through at least one lead-delivery lumen of said guide-catheter to a location adjacent said portion of tissue; and

removing said guide catheter so that said medical electrical lead remains in the location adjacent said portion of tissue.