Method and device for acquiring data for diffusion-weighted magnetic resonance imaging

• US 20040071324A1
• Filed: 08/28/2003
• Published: 04/15/2004
• Est. Priority Date: 02/28/2001
• Status: Active Grant

• Current Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Original Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Inventors: Norris, David, Driesel, Wolfgang
• Granted Patent: US 6,842,000 B2
• Time in Patent Office: Days
• US Class Current: 382/128
• CPC Class Codes: G01R 33/56341 Diffusion imaging
• CPC Class Codes: G01R 33/56509 due to motion, displacement or flow, e.g. gradient moment nulling G01R33/567 takes precedence

Abstract

The invention relates to a magnetic resonance imaging method which is characterized in that the transversal magnetization excited in the object to be imaged is diffusion-weighted before the useful echo (E) used for the reconstruction of an image is induced. When the object is moved, phase changes in the diffusion-weighted transversal magnetization can occur that lead to artifacts in the reconstructed image. These disturbing phase changes are measured by analyzing a navigation signal (N₁, N₂) that is generated before the useful signal is generated. The result of the measurement is used to change the phase characteristics of the transversal magnetization online by a correctional intervention (C₀, C₁, C₂) in such a way that the measured phase changes are compensated. The invention further relates to a magnetic resonance device for carrying out said method.

Claims

1. Method of acquiring data for the illustration of an image which shows the spatial distribution of the magnetic resonance behaviour of an object within a selected object area which is disposed in a stationary and the most homogenous possible longitudinal magnetic field and is subjected to a sequence of HF-pulses and magnetic field gradient pulses in different spatial directions, such that a sequence of useful echoes (E), encoded in dependence upon the location, of the magnetisation which is transversal with respect to the stationary magnetic field is produced which useful echoes are acquired as a data record for the reconstruction of the image to be illustrated,

wherein between an HF-pulse which excites the transversal magnetisation and the production of the useful echoes (E) a diffusion-weighting sequence is introduced which leads to an attenuation in the transversal magnetisation which is dependent upon the diffusion procedures in the selected object area,

and wherein from this diffusion-weighted transversal magnetisation a navigator signal is produced by echo-generation (N₁, N₂, N₃) and its characteristic is used as information for the correction of image artefacts which are produced by movement of the object

characterised in that

prior to the production of the useful echoes (E) at least one of those interference variables in the phase characteristic of the navigator signal (N₁, N₂, N₃), which would cause the said image artefacts, is measured,

and that the result of this measurement is utilised in order to change the phase characteristic of the transversal magnetisation, from which the useful echoes are generated, for the purpose of compensating for the measured variable.

2. Method as claimed in claim 1, characterised in that the zero order phase shift in the navigator signal (e.g. N₁) is measured as an interference variable in relation to a reference phase which is produced when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and that a homogenous magnetic field pulse (C₀) which is dimensioned to compensate

for this phase shift is applied in the direction of the stationary longitudinal magnetic field.

3. Method as claimed in claim 1, characterised in that the zero order phase shift Δ

Φ

is measured as an interference variable in relation to a reference phase which is produced when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and that the phase of subsequent HF-pulses is changed to such an extent as to compensate for the measured phase shift Δ

Φ

.

4. Method as claimed in claim 3, characterised in that the useful echoes (E) are produced using refocussing HF-pulses,

and that the phase of these HF-refocussing pulses is changed in each case by Δ

Φ

+π

or Δ

Φ

−

π

.

5. Method as claimed in claim 3, characterised in that the transversal magnetisation for the useful echoes is newly excited by at least one HF-excitation pulse which is generated after the diffusion-weighting,

and that prior to the first new excitation of the transversal magnetisation for the useful echoes an HF-pulse with a flip-angle of 90°

is applied which drives the previous transversal magnetisation back in the longitudinal direction (DEFT-pulse) and its phase is shifted by Δ

Φ

.

6. Method as claimed in any one of claims 2 to 5, characterised in that the reference phase is determined by measuring the phase of a corresponding navigator signal which is generated in at least one preceding reference experiment with negligibly weak diffusion-weighting or with no diffusion-weighting.

7. Method as claimed in any one of the preceding claims, characterised in that the spatial gradient of the phase of the transversal magnetisation is measured as an interference variable,

and that a magnetic field gradient pulse (C₁, C₂, C₃) which is dimensioned to compensate for this phase gradient is applied.

8. Method as claimed in claim 7, characterised in that the navigator signal is generated in the form of at least two navigator echoes (N₁, N₂, N₃), each of which is frequency-encoded and detected in dependence upon the location in a spatial direction which is allocated to precisely this echo,

and that each detected navigator echo (N₁, N₂, N₃) is used to determine the phase gradient of the transversal magnetisation which moves in the respectively allocated spatial direction,

and that in each of the allocated spatial directions a respective magnetic field gradient pulse (C₁, C₂, C₃) is generated which compensates for the phase gradient of the transversal magnetisation which is determined for this direction.

9. Method as claimed in claim 8, characterised in that two of the navigator echoes (N₁, N₂) are frequency-encoded in different and preferably mutually perpendicular spatial directions in the particular plane which is perpendicular to the direction of the magnetic field gradients applied for the diffusion-weighting.

10. Method as claimed in claim 8, characterised in that two of the navigator echoes (N₁, N₂) are frequency-encoded in different and preferably mutually perpendicular spatial directions in the particular plane which corresponds to the image plane which is to be illustrated.

11. Method as claimed in claim 8 or 9, characterised in that a third one of the navigator echoes (N₃) is frequency-encoded in the particular spatial direction which is perpendicular to the plane of the frequency-encoding directions of the two other navigator echoes (N₁, N₂).

12. Method as claimed in any one of claims 8 to 11, characterised in that

in order to determine the phase gradient the time shift Δ

t of the maximum of the relevant navigator echo (N₁, N₂, N₃) is measured with respect to a reference time, at which the maximum would appear when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and that the time integral of the amplitude over the duration of the magnetic field gradient pulse (C₁, C₂, C₃), which compensates for the phase gradient, is dimensioned to be equal to −

Δ

t·

G_nav, where G_nav is the amplitude of the magnetic field gradient which frequency-encodes the navigator echo.

13. Method as claimed in claim 12, characterised in that the reference time is determined by measuring the time of the maximum of a corresponding navigator echo which is generated in at least one preceding reference experiment with negligibly weak diffusion-weighting or with no diffusion-weighting.

14. Method as claimed in claim 7, characterised in that the navigator signal is scanned over the area of the K-space of a plane which is perpendicular to the direction of the magnetic field gradients applied for diffusion-weighting,

and that the value and direction of the phase gradient of the transversal magnetisation are determined from the shift, which the location of the maximum signal intensity has in this K-space with respect to the origin of the co-ordinates.

15. Method as claimed in claim 7, characterised in that the navigator signal is scanned over the area of the K-space of a plane which corresponds to the image plane which is to be illustrated,

and that the value and direction of the phase gradient of the transversal magnetisation are determined from the shift which the location of the maximum signal intensity has in this K-space with respect to the origin of the co-ordinates.

16. Method as claimed in claim 14 or 15, characterised in that the scanning performed over the area of the K-space is a spiral-scanning procedure.

17. Device for the acquisition of data for the illustration of an image which shows the spatial distribution of the magnetic resonance behaviour of an object within a selected location area, having

a device (11, 11a, 21, 22a) for generating a homogenous magnetic field along a longitudinal axis in the object area to be examined,

a device (15, 23) for generating HF-pulses which act upon the object area, devices (12, 13, 14, 22) for generating magnetic field gradients in different spatial directions in the object area,

a device (50) for selecting the magnetic resonance signals emanating from the object area,

and a control device (30, 40, 60) which upon activation controls the generation of the HF-pulses and the magnetic field gradients and the selection of the magnetic resonance signals in such a manner that the object area is subjected to a sequence of HF- and magnetic field gradient pulses, in order to produce a sequence of useful echoes (E), encoded in dependence upon the location, of the magnetisation which is transversal to the stationary magnetic field, which useful echoes form the data record for the reconstruction of the image to be illustrated, and in order to introduce between an HF-pulse, which excites the transversal magnetisation, and the production of the useful echoes (E), a diffusion-weighting sequence which leads to an attenuation in the transversal magnetisation which is dependent upon diffusion procedures in the selected object area, and in order from this diffusion-weighted transversal magnetisation to produce a navigator signal by echo-generation (N₁, N₂, N₃), the characteristic of said navigator signal being used as information for the correction of image artefacts which are produced by movement of the object,

characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

prior to the production of the useful echoes (E) at least one of those interference variables in the phase characteristic of the navigator signal (N₁, N₂, N₃), which would cause the said image artefacts, is measured

and the phase characteristic of the transversal magnetisation, from which the useful echoes are generated, is changed for the purpose of compensating for the respectively measured variable.

18. Device as claimed in claim 17, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the zero order phase shift in the navigator signal (e.g. (N₁) is measured as an interference variable in relation to a reference phase which is produced when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and a homogenous magnetic field pulse (C₀) which is dimensioned to compensate for this phase shift is applied in the direction of the stationary longitudinal magnetic field.

19. Device as claimed in claim 17, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the zero order phase shift Δ

Φ

is measured as an interference variable in relation to a reference phase which is produced when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and the phase of subsequent HF-pulses is changed to such an extent as to compensate for the measured phase shift Δ

Φ

.

20. Device as claimed in claim 19, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the useful echoes (E) are generated using refocussing HF-pulses,

and the phase of these HF-refocussing pulses is changed in each case by Δ

Φ

+π

or Δ

Φ

−

π

.

21. Device as claimed in claim 19, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the transversal magnetisation for the useful echoes is newly excited by means of at least one HF-excitation pulse which is generated after the diffusion-weighting,

and prior to the first new excitation of the transversal magnetisation for the useful echoes an HF-pulse with a flip-angle of 90°

is applied which drives the previous transversal magnetisation back in the longitudinal direction (DEFT-pulse) and its phase is shifted by Δ

Φ

.

22. Device as claimed in any one of claims 18 to 21, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the reference phase is determined by measuring the phase of a corresponding navigator signal which is generated in at least one preceding reference experiment with negligibly weak diffusion-weighting or with no diffusion-weighting.

23. Device as claimed in any one of claims 17 to 22, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the spatial gradient of the phase of the transversal magnetisation is measured as an interference variable,

and a magnetic field gradient pulse (C₁, C₂, C₃) which is dimensioned to compensate for this phase gradient is applied.

24. Device as claimed in claim 23, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the navigator signal is generated in the form of at least two navigator echoes (N₁, N₂, N₃), each of which is frequency-encoded and detected in dependence upon the location in a spatial direction which is allocated to precisely this echo,

and each detected navigator echo (N₁, N₂, N₃) is used to determine the phase gradient of the transversal magnetisation which moves in the respectively allocated spatial direction,

and in each of the allocated spatial directions a respective magnetic field gradient pulse (C₁, C₂, C₃) is generated which compensates for the phase gradient of the transversal magnetisation which is determined for this direction.

25. Device as claimed in claim 24, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

two of the navigator echoes (N₁, N₂) are frequency-encoded in different and preferably mutually perpendicular spatial directions in the particular plane which is perpendicular to the direction of the magnetic field gradients applied for the diffusion-weighting.

26. Device as claimed in claim 24, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

two of the navigator echoes (N₁, N₂) are frequency-encoded in different and preferably mutually perpendicular spatial directions in the particular plane which corresponds to the image plane which is to be illustrated.

27. Device as claimed in claim 25 or 26, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

a third one of the navigator echoes (N₃) is frequency-encoded in the particular spatial direction which is perpendicular to the plane of the frequency-encoding directions of the two other navigator echoes (N₁, N₂).

28. Device as claimed in claim 24 to 27, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

in order to determine the phase gradient the time shift Δ

t of the maximum of the relevant navigator echo (N₁, N₂, N₃) is measured with respect to a reference time, at which the maximum would appear when there is no diffusion-weighting or the diffusion-weighting is negligibly weak,

and the time integral of the amplitude over the duration of the magnetic field gradient pulse (C₁, C₂, C₃), which compensates for the phase gradient, is dimensioned to be equal to −

Δ

t·

G_nav, where G_nav is the amplitude of the magnetic field gradient which frequency-encodes the navigator echo.

29. Device as claimed in claim 28, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the reference point is determined by measuring the time of the maximum of a corresponding navigator echo which is generated in at least one preceding reference experiment with negligibly weak diffusion-weighting or with no diffusion-weighting.

30. Device as claimed in claim 23, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the navigator signal is scanned over the area of the K-space of a plane which is perpendicular to the direction of the magnetic field gradients applied for the diffusion-weighting,

and the value and direction of the phase gradient of the transversal magnetisation are determined from the shift which the location of the maximum signal intensity has in this K-space with respect to the origin of the co-ordinates.

31. Device as claimed in claim 23, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the navigator signal is scanned over the area of the K-space of a plane which corresponds to the image plane which is to be illustrated,

and the value and direction of the phase gradient of the transversal magnetisation are determined from the shift which the location of the maximum signal intensity has in this K-space with respect to the origin of the co-ordinates.

32. Device as claimed in claim 30 or 31, characterised by a configuration of the control device (30, 40, 60) such that upon activation thereof

the scanning performed over the area of the K-space is a spiral-scanning procedure.