Preventive or therapeutic agent for inflammatory bowel disease comprising IL-6 antagonist as an active ingredient

• US 20040071706A1
• Filed: 10/03/2003
• Published: 04/15/2004
• Est. Priority Date: 03/17/1998
• Status: Active Grant

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Inventors: Yamamoto, Mitsunari, Ito, Hiroaki, Kishimoto, Tadamitsu
• Granted Patent: US 7,824,674 B2
• Time in Patent Office: Days
• US Class Current: 424/145.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: C07K 16/2866 against receptors for cytokines, lymphokines, interferons

Abstract

A preventive or therapeutic agent for inflammatory bowel disease such as Crohn'"'"'s disease and ulcerative colitis said agent comprising as an active ingredient an interleukin-6 (IL-6) antagonist such as an antibody directed against IL-6 receptor.

Claims

1. A preventive or therapeutic agent for inflammatory bowel disease comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

2. The preventive or therapeutic agent according to claim 1 wherein the IL-6 antagonist is an antibody against IL-6 receptor.

3. The preventive or therapeutic agent according to claim 2 wherein the antibody against IL-6 receptor is a monoclonal antibody against IL-6 receptor.

4. The preventive or therapeutic agent according to claim 3 wherein the antibody against IL-6 receptor is a monoclonal antibody against human IL-6 receptor.

5. The preventive or therapeutic agent according to claim 3 wherein the antibody directed against IL-6 receptor is a monoclonal antibody against mouse IL-6 receptor.

6. The preventive or therapeutic agent according to any of claims 2 to 5 wherein the antibody against IL-6 receptor is a recombinant antibody.

7. The preventive or therapeutic agent according to claim 4 wherein the monoclonal antibody against human IL-6 receptor is PM-1 antibody.

8. The preventive or therapeutic agent according to claim 5 wherein the monoclonal antibody against mouse IL-6 receptor is MR16-1 antibody.

9. The preventive or therapeutic agent according to any of claims 2 to 4 wherein the antibody against IL-6 receptor is a chimeric or humanized antibody against IL-6 receptor.

10. The preventive or therapeutic agent according to claim 9 wherein the humanized antibody against IL-6 receptor is a humanized PM-1 antibody.

11. The preventive or therapeutic agent according to any of claims 1 to 10 wherein the inflammatory bowel disease is Crohn'"'"'s disease or ulcerative colitis.

12. An agent for suppressing weight loss in inflammatory bowel disease said agent comprising an IL-6 antagonist as an active ingredient.

13. An agent for suppressing weight loss in inflammatory bowel disease said agent comprising an antibody against IL-6 receptor as an active ingredient.

14. A method of preventing or treating inflammatory bowel disease which method comprises administering an interleukin-6 (IL-6) antagonist to the subject.

15. The method according to claim 14 wherein the IL-6 antagonist is an antibody against IL-6 receptor.

16. The method according to claim 15 wherein the antibody against IL-6 receptor is a monoclonal antibody against IL-6 receptor.

17. The method according to claim 16 wherein the antibody against IL-6 receptor is a monoclonal antibody against human IL-6 receptor.

18. The method according to claim 16 wherein the antibody against IL-6 receptor is a monoclonal antibody against mouse IL-6 receptor.

19. The method according to any of claims 15 to 18 wherein the antibody against IL-6 receptor is a recombinant antibody.

20. The method according to claim 17 wherein the monoclonal antibody against human IL-6 receptor is PM-1 antibody.

21. The method according to claim 18 wherein the monoclonal antibody against mouse IL-6 receptor is MR16-1 antibody.

22. The method according to any of claims 15 to 17 wherein the antibody against IL-6 receptor is a chimeric antibody or a humanized antibody against IL-6 receptor.

23. The method according to claim 0.22 wherein the humanized antibody against IL-6 receptor is a humanized PM-1 antibody.

24. The method according to any of claims 14 to 23 wherein the inflammatory bowel disease is Crohn'"'"'s disease or ulcerative colitis.

25. A method of suppressing weight loss in inflammatory bowel disease which method comprises administering an IL-6 antagonist to the subject.

26. A method of suppressing weight loss in inflammatory bowel disease which method comprises administering an antibody against IL-6 receptor to the subject.

27. The use of an interleukin-6 (IL-6) antagonist for the production of a preventive or therapeutic agent for inflammatory bowel disease.

28. The use according to claim 27 wherein the IL-6 antagonist is an antibody against IL-6 receptor.

29. The use according to claim 28 wherein the antibody against IL-6 receptor is a monoclonal antibody against IL-6 receptor.

30. The use according to claim 29 wherein the antibody against IL-6 receptor is a monoclonal antibody against human IL-6 receptor.

31. The use according to claim 29 wherein the antibody against IL-6 receptor is a monoclonal antibody against mouse IL-6 receptor.

32. The use according to any of claims 28 to 31 wherein the antibody against IL-6 receptor is a recombinant antibody.

33. The use according to claim 30 wherein the monoclonal antibody against human IL-6 receptor is PM-1 antibody.

34. The use according to claim 31 wherein the monoclonal antibody against mouse IL-6 receptor is MR16-1 antibody.

35. The use according to any of claims 28 to 30 wherein the antibody against IL-6 receptor is a chimeric or humanized antibody against IL-6 receptor.

36. The use according to claim 35 wherein the humanized antibody against IL-6 receptor is a humanized PM-1 antibody.

37. The use according to any of claims 27 to 36 wherein the inflammatory bowel disease is Crohn'"'"'s disease or ulcerative colitis.

38. The use of an IL-6 antagonist for the production of an agent for suppressing weight loss in inflammatory bowel disease.

39. The use of antibody directed against IL-6 receptor for the production of an agent for suppressing weight loss in inflammatory bowel disease.