Composition and device structure for iontophoresis

• US 20040071765A1
• Filed: 10/01/2003
• Published: 04/15/2004
• Est. Priority Date: 09/01/1999
• Status: Abandoned Application

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Higo, Naruhito, Arimoto, Tetsuya, Kuzumaki, Noriyuki, Adachi, Hirotoshi
• Application Number:
  US10/674,419
• Publication Number:
  US 20040071765A1
• Time in Patent Office: Days
• US Class Current: 424/449
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 9/06 Antiarrhythmics

Abstract

Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.

Claims

1. A composition for iontophoresis comprising at least one partially ionized active ingredient and a water swelling polymer which has a pH adjusting function.

2. The composition for iontophoresis as claimed in claim 1 wherein the water swelling polymer is at least either a weakly basic or weakly acidic water swelling polymer showing a characteristic of pH-dependent solubility.

3. The composition for iontophoresis as claimed in claim 1 wherein the water swelling polymer comprises at least either a polyamine of primary, secondary or tertiary amines or a carboxylic acid.

4. The composition for iontophoresis as claimed in claim 1 wherein the water swelling polymer comprises at least either a basic methacrylate copolymer or an acidic methacrylate copolymer.

5. The composition for iontophoresis as claimed in claim 4 wherein the basic methacrylate copolymer is soluble at lower pH than around weak acidic to neutral range and hardly soluble at higher pH than that.

6. The composition for iontophoresis as claimed in claim 4 wherein the acidic methacrylate copolymer is soluble at higher pH than around weakly acidic to weakly basic range and hardly soluble at lower pH than that.

7. The composition for iontophoresis as claimed in claim 4 wherein the basic methacrylate copolymer is aminoalkyl methacrylate copolymer E.

8. The composition for iontophoresis as claimed in claim 4 which comprises a basic methacrylate copolymer and further contains at least either hydrochloric acid or a weakly acidic material with at least one pKa within a range of 3 to 9.

9. The composition for iontophoresis as claimed in claim 8 wherein the weakly acidic material is at least one selected from organic acids and acidic amino acids.

10. The composition for iontophoresis as claimed in claim 4 wherein the acidic methacrlic acid copolymer is at least either methacrlic acid copolymer L or methacrlic acid copolymer S.

11. The composition for iontophoresis as claimed in claim 4 which comprises an acidic methacrylate copolymer and further contains a weakly basic material with at least one pKa within a range of 3 to 10.

12. The composition for iontophoresis as claimed in claim 11 wherein the weakly basic material is at least one selected from salts of organic acids and basic amino acids.

13. An electrically conductive layer for iontophoresis which comprises the composition for iontophoresis as claimed in any of claims 1 to 12.

14. A device structure for iontophoresis which is provided with the electrically conductive layer containing at least one of partially ionized active ingredients and a water swelling polymer having a pH adjusting function, and electrodes to supply electric current to said electrically conductive layer.

15. The device structure for iontophoresis as claimed in claim 14 wherein the active ingredient is a cationic material and the water swelling polymer is a basic methacrylate copolymer or a mixture of the basic methacrylate copolymer and the acidic methacrylate copolymer.

16. The device structure for iontophoresis as claimed in claim 14 wherein said active ingredient is an anionic material and said water swelling polymer is an acidic methacrylate copolymer or a mixture of the basic methacrylate copolymer and the acidic methacrylate copolymer.