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Methods for altering cell fate to generate T-cells specific for an antigen of interest

  • US 20040072288A1
  • Filed: 04/30/2003
  • Published: 04/15/2004
  • Est. Priority Date: 12/22/2000
  • Status: Active Grant
First Claim
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1. A method of reprogramming a cell to express a T-cell receptor (TCR) reactive with an antigen of interest, said method comprising the steps of:

  • (a) incubating a nucleus from a donor cell with a reprogramming media comprising a T-cell factor under conditions that allow the removal of a factor from said nucleus or the addition of a factor from said reprogramming media to said nucleus;

    (b) inserting said nucleus or a chromatin mass formed from said nucleus into a recipient cell or cytoplast, thereby forming a reprogrammed cell; and

    (c) selecting said reprogrammed cell that expresses a TCR reactive with an antigen of interest.

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