Method and compositions for inhibiting tumorigenesis
First Claim
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1. A method of proliferating a mammalian cell from the Central Nervous System (CNS) and its subsequent differentiation to become a neuron comprising culturing the cell in the presence of an agent that stimulates the SHH-GLI pathway.
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Abstract
The present invention discloses methods of producing neuronal cells from stem cells, particularly from adult brain stem cells. The use of such neuronal cells in the treatment and/or prevention of neurological diseases, conditions and/or injuries is also disclosed. In addition, the present invention provides a novel source of neuronal cells for use as a laboratory tool.
21 Citations
28 Claims
- 1. A method of proliferating a mammalian cell from the Central Nervous System (CNS) and its subsequent differentiation to become a neuron comprising culturing the cell in the presence of an agent that stimulates the SHH-GLI pathway.
- 10. A method of generating a neuron from an adult, perinatal or post-natal neural stem cell comprising culturing the stem cell in the presence of an agent that stimulates the SHH-GLI pathway.
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21. A method for treating and/or preventing a neurologic or neurodegenerative disease, disorder or condition in a mammal, comprising transplanting into the brain of the mammal an expression vector that encodes sonic hedgehog or an active fragment thereof.
- 24. A method of treating tumors comprising administering an agent that blocks endogenous SHH and/or GLI signaling.
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