Apparatus and method for mixing a film of fluid
First Claim
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1. A method comprising:
- providing first and second subtrates and a seal;
placing the second substrate on top of the seal and first substrate so as to define a closed chamber therebetween, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both inner surfaces, and wherein at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides; and
introducing a fluid containing a plurality of components into the closed chamber so as to provide a quantity of fluid therein in contact with both inner surfaces.
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Abstract
A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
52 Citations
23 Claims
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1. A method comprising:
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providing first and second subtrates and a seal;
placing the second substrate on top of the seal and first substrate so as to define a closed chamber therebetween, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both inner surfaces, and wherein at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides; and
introducing a fluid containing a plurality of components into the closed chamber so as to provide a quantity of fluid therein in contact with both inner surfaces. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. The method of 1 wherein the at least one of the inner surfaces is functionalized with polypeptides.
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17. An apparatus comprising
first and second subtrates and a seal, wherein the second substrate is positioned on top of the seal and first substrate so as to define a closed chamber therebetween, said chamber retaining a quantity of fluid therein so that the fluid is in contact with both inner surfaces, and wherein at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides.
Specification