Systems and methods for detecting vulnerable plaque

• US 20040073132A1
• Filed: 05/07/2003
• Published: 04/15/2004
• Est. Priority Date: 05/07/2002
• Status: Abandoned Application

• Current Assignee: Duane Dickens, Jesus Flores, Thomas H. Campbell, Tracy Maahs
• Original Assignee: Duane Dickens, Jesus Flores, Thomas H. Campbell, Tracy Maahs
• Inventors: Campbell, Thomas H., Flores, Jesus, Dickens, Duane, Maahs, Tracy
• Application Number:
  US10/431,671
• Publication Number:
  US 20040073132A1
• Time in Patent Office: Days
• US Class Current: 600/549
• CPC Class Codes: A61B 2560/0437 Trolley or cart-type apparatus
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/6858 with a distal basket, e.g. expandable basket
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/7435 Displaying user selection data, e.g. icons in a graphical user interface

Abstract

A thermography system that can be used in the vasculature of a patient, or elsewhere, with a catheter and an instrument configured to graphically display thermography data from the catheter. Sensors on the catheter may measure blood temperature, wall temperature of a body vessel or both as well as differences between blood temperature and wall temperature. Temperature differences from different locations of a patient'"'"'s body vessel can be measured contemporaneously, compared and displayed on the graphical display which may be a graphic user interface in some embodiments.

Claims

1. A thermography system, comprising:

a thermography catheter having a thermal sensor on a distal section thereof;

a system controller coupled to the thermal sensor; and

a display configured to graphically display thermography data from the thermal sensor.

2. The thermography system of claim 1 wherein the display comprises a graphic user interface.

3. The thermography system of claim 1 wherein the thermography catheter comprises a plurality of thermal sensors in a substantially annular array and the display is configured to display thermography data from the sensors in a series of concentric rings each of which are divided into circumferential sections with each circumferential section correlating to a distinct thermal sensor and with each concentric ring representing a different thermography data point.

4. The thermography system of claim 3 wherein display comprises about 3 to about 20 circumferential sections.

5. The thermography system of claim 3 wherein the display comprises about 4 to about 8 circumferential sections.

6. The thermography system of claim 3 wherein each circumferential section displays a color that is a function of the temperature of the thermal sensor corresponding to the circumferential section.

7. The thermography system of claim 3 wherein difference between blood temperature and the temperature of a wall of a body vessel adjacent the blood is displayed in a circumferential section.

8. The thermography system of claim 3 wherein blood temperature is displayed in a center portion of the display.

9. The thermography system of claim 1 wherein the thermography catheter comprises a plurality of thermal sensors in a substantially annular array and wherein thermography data from the thermal sensors is displayed in an annular ring on a screen of the display that is divided into circumferential sections with each section corresponding to a thermal sensor.

10. The thermography system of claim 9 wherein each circumferential section displays a color that is a function of the temperature of the thermal sensor corresponding to the circumferential section.

11. The thermography system of claim 9 wherein difference between blood temperature and the temperature of a wall of a body vessel adjacent the blood is displayed in a circumferential section.

12. The thermography system of claim 9 wherein blood temperature is displayed in a center portion of the annular ring.

13. The thermography system of claim 1 wherein the system controller comprises a CPU.

14. The thermography system of claim 1 wherein the thermal sensor is coupled by a conductor to a connector at a proximal end of the catheter and the connector is coupled to the system controller by an interface cable.

15. The thermography system of claim 1 further comprising a pull back device configured to couple to a proximal portion of the catheter and exert an axial force on the catheter.

16. The thermography system of claim 15 further comprising a position encoder coupled to the pull back device and coupled to the system controller wherein the position encoder is configured to transmit position data of the catheter to the system controller.

17. A thermography system, comprising:

a thermography catheter having a thermal sensor on a distal section thereof and a plurality of thermal sensors in a substantially annular array;

a system controller coupled to the thermal sensors; and

a display configured to graphically display thermography data from the thermal sensor in a series of concentric rings divided into circumferential sections with each circumferential section correlating to a distinct thermal sensor and with adjacent rings representing different thermography data points.

18. The thermography system of claim 17 wherein the display comprises a graphic user interface.

19. A thermography system, comprising:

a thermography catheter having a thermal sensor on a distal section thereof;

a system controller coupled to the thermal sensor; and

a display configured to graphically display thermography data from the thermal sensor in an annular ring on a screen of the display that is divided into circumferential sections.

20. The thermography system of claim 19 wherein the display comprises a graphic user interface.

21. A thermography instrument, comprising:

a system controller coupled to a thermography data input; and

a display configured to graphically display thermography data from the thermography data input.

22. The thermography instrument of claim 21 wherein the display comprises a graphic user interface.

23. The thermography instrument of claim 21 wherein the system controller is coupled to a plurality of thermography data inputs and wherein the display is configured to display thermography data in a series of concentric rings divided into circumferential sections with each circumferential section correlating to a distinct thermography data input and with adjacent rings representing different thermography data points.

24. The thermography instrument of claim 23 wherein thermography data is displayed such that each circumferential section has a color which is a function of the thermography data from each thermography data input.

25. The thermography instrument of claim 23 wherein difference between blood temperature and the temperature of tissue adjacent the blood is displayed.

26. The thermography system of claim 23 wherein blood temperature is displayed in a center portion of the display.

27. The thermography instrument of claim 21 wherein the thermography data is displayed in an annular ring on a screen of the display that is divided into circumferential sections.

28. The thermography instrument of claim 27 wherein a difference between blood temperature and temperature of tissue adjacent the blood is displayed.

29. The thermography instrument of claim 27 wherein blood temp is displayed in center of display.

30. The thermography system of claim 21 wherein the system controller comprises a CPU.

31. The thermography system of claim 21 wherein the thermal sensor is coupled by a conductor to a connector at a proximal end of the catheter and the connector is coupled to the system controller by an interface cable.

32. The thermography instrument of claim 21 further comprising a pedestal and a keyboard coupled to the display.

33. A thermography instrument, comprising:

a system controller coupled to a thermography data input; and

a display coupled to the system controller configured to graphically display thermography data from at least one data input in a series of concentric rings divided into circumferential sections with each circumferential section correlating to a distinct thermography data input and with adjacent rings representing different thermography data points.

34. The thermography instrument of claim 33 wherein the display comprises a graphic user interface.

35. A thermography instrument, comprising:

a system controller coupled to a plurality of thermography data inputs; and

a display coupled to the system controller and configured to graphically display thermography data from the data inputs in an annular ring on a screen of the display that is divided into circumferential sections, with each circumferential section corresponding to a distinct thermography data input.

36. The thermography instrument of claim 35 wherein the display comprises a graphic user interface.

37. A method of displaying thermography data, comprising:

providing a thermography system, comprising;

a thermography catheter having a thermal sensor on a distal section thereof;

a system controller coupled to the thermal sensor;

a display configured to graphically display thermography data from the thermal sensor;

positioning the thermography catheter in a body of a patient;

detecting thermography data at the thermal sensor; and

graphically displaying the thermography data on display.

38. The method of claim 37 wherein the thermography catheter is positioned within a body vessel of the patient prior to detecting the thermography data.

39. The method of claim 38 wherein the body vessel comprises a coronary artery.

40. The method of claim 37 wherein the display comprises a graphic user interface.

41. The method of claim 37 wherein the thermography catheter comprises a plurality of thermal sensors in a substantially annular array and the display graphically displays the thermography data in a series of concentric rings divided into circumferential sections with each circumferential section correlating to a distinct thermal sensor and with adjacent rings representing different thermography data points.

42. The method of claim 41 wherein temperature data is displayed by the display of a color in each of the circumferential sections and wherein the color is a function of the thermography data from each thermal sensor corresponding to the circumferential section.

43. The method of claim 42 wherein the thermography data displayed comprises a difference between blood temperature and temperature of a body vessel wall adjacent the blood.

44. The method of claim 37 wherein blood temperature is displayed in center of display.

45. The method of claim 37 wherein the thermography data is displayed in an annular ring on a screen of the display that is divided into circumferential sections.

46. The method of claim 45 wherein the thermography data displayed in each circumferential section comprises a difference between blood temperature and temperature of a body vessel wall adjacent the blood.

47. The method of claim 45 wherein blood temperature is displayed in center portion of the annular ring.

48. The method claim 37 wherein the system controller comprises a CPU that converts thermography data from the thermal sensor to graphical data that is communicated to the display.

49. The method of claim 37 wherein the thermal sensor is coupled by a conductor to a connector at a proximal end of the catheter and the connector is coupled to the system controller by an interface cable.

50. The method of claim 41 wherein detecting thermography data comprises detecting temperature data from thermal sensors at a plurality of axial points while the catheter is being axially translated within a body vessel and each concentric ring of the display corresponds to a distinct axial position within the body vessel.

51. The method of claim 50 wherein the thermography system further comprises a mechanical pull back device coupled to a proximal portion of the catheter and the catheter is axially translated by the mechanical pull back device.

52. The method of claim 51 wherein the thermography system further comprises an axial position encoder coupled to the mechanical pull back device and coupled to the system controller and wherein position data of the catheter is communicated from the encoder to the system controller during the axial translation of the catheter.

53. A method of displaying thermography data, comprising:

providing a thermography instrument, comprising;

a system controller coupled to a thermography data input; and

a display configured to graphically display thermography data from the thermography data input;

detecting thermography data from the thermography data input; and

graphically displaying the thermography data on the display.

54. The method of claim 53 wherein the display comprises a graphic user interface.

55. The method of claim 53 wherein the system controller is coupled to a plurality of thermography data inputs and thermography data from the inputs is displayed in a series of concentric rings divided into circumferential sections with each circumferential section correlating to a distinct thermography data input and with adjacent rings representing different thermography data points.

56. The method of claim 55 wherein thermography data is displayed as a color that is a function of the thermography data from each thermography data input for each circumferential section.

57. The method of claim 53 wherein the system controller is coupled to a plurality of thermography data inputs and thermography data from the inputs is displayed in an annular ring on a screen of the display that is divided into circumferential sections.

58. The method of claim 57 wherein thermography data is displayed as a color that is a function of the thermography data from each thermography data input for each circumferential section.

59. The method claim 53 wherein the system controller comprises a CPU that converts thermography data from the thermography data input to graphical data that is communicated to the display.

60. An apparatus for measuring the thermal characteristics of blood vessel in vivo, comprising:

a catheter having a proximal end, a distal end, and a distal section;

an expandable slotted body located at the distal section of said catheter, said expandable slotted body comprising one or more slotted body arms;

one or more vessel wall temperature sensors positioned on said one or more slotted body arms, said one or more vessel wall temperature sensors configured to make contact with a vessel wall when said expandable slotted body is in an expanded state; and

one or more blood temperature sensors positioned on said one or more slotted body arms in a configuration which prevents contact between said one or more blood temperature sensors and said vessel wall when said expandable slotted body is in an expanded state.

61. A thermography catheter having an expandable member disposed on a distal section thereof and a plurality of thermal sensors with a first thermal sensor configured to be at an outer most radial position from a longitudinal axis of the distal section of the catheter with the expandable member in an expanded state and a second thermal sensor configured to disposed radially inward of the first thermal sensor with the expandable member in an expanded state.

62. A thermography method comprising measuring the temperature of a body vessel wall and the temperature of blood adjacent to the body vessel wall contemporaneously.

63. A thermography method, comprising:

providing a catheter having an expandable member disposed on a distal section thereof and a plurality of thermal sensors on a distal section thereof;

positioning the distal section of the catheter in a body vessel;

detecting the temperature of a site on the body vessel; and

detecting the temperature of blood adjacent the site of the body vessel contemporaneously with the detection of the temperature of the site on the body vessel.

64. The method of claim 63 further comprising displaying the temperature of the body vessel site and the temperature of the blood on a graphical display.

65. The method of claim 64 further comprising calculating the difference between the blood temperature and the body vessel wall temperature and displaying the result in a graphical color display wherein the color is a function of the temperature difference.

66. A thermography instrument for displaying thermography data taken from a site within a patient, comprising:

a system controller coupled to a thermography data input; and

a display coupled to the system controller and configured to graphically display thermography data from the thermography data input on a graph having thermography data from the thermography data input on a first axis and an axial position of a site from which the thermography data was taken on a second axis.

67. The thermography instrument of claim 66 wherein the display comprises a graphic user interface.

68. The thermography instrument of claim 66 wherein the system controller comprises a plurality of thermography data inputs and thermography data from each of the thermography data inputs is displayed in a graph having a different color from graphs of thermography data taken from other thermography data inputs.

69. The thermography instrument of claim 66 wherein a difference between blood temperature and the temperature of tissue adjacent the blood is displayed on the first axis.