Method of regenerating human tissue

• US 20040076605A1
• Filed: 08/29/2003
• Published: 04/22/2004
• Est. Priority Date: 09/03/2002
• Status: Abandoned Application

• Current Assignee: Regenetech, Inc.
• Original Assignee: Regenetech, Inc.
• Inventors: Rudd, Donnie
• Application Number:
  US10/652,375
• Publication Number:
  US 20040076605A1
• Time in Patent Office: Days
• US Class Current: 424/85.1
• CPC Class Codes: A61K 38/193 Colony stimulating factors [CSF]

Abstract

A method for regenerating a human individual'"'"'s tissue is disclosed comprising determining the white blood cell content of the individual, administering granulocyte colony-stimulating factor to the individual while monitoring the white blood cell content of the individual, continuing the administration of the granulocyte colony-stimulating factor to the individual until the white blood cell content is more than twice its original amount, maintaining the administration of the granulocyte colony-stimulating factor to the individual at a level that maintains the white blood cell content at least at twice its original amount, monitoring the individual'"'"'s tissue to be regenerated, and discontinuing the administration of the granulocyte colony-stimulating factor to the individual when the tissue regenerates. Also disclosed is the above method which includes removing blood cells from the individual, controllably expanding the blood cells while maintaining their three-dimensional geometry and their cell-to-cell geometry and reintroducing the blood cells into the individual while administering the granulocyte colony-stimulating factor.

Claims

1. A method for regenerating a human individual'"'"'s tissue comprising determining the white blood cell content of the individual, administering granulocyte colony-stimulating factor to the individual while monitoring the white blood cell content of the individual, continuing the administration of the granulocyte colony-stimulating factor to the individual until the white blood cell content is more than twice its original amount, maintaining the administration of the granulocyte colony-stimulating factor to the individual at a level that maintains the white blood cell content at least at twice its original amount, monitoring the individual'"'"'s tissue to be regenerated, and discontinuing the administration of the granulocyte colony-stimulating factor to the individual when the tissue regenerates.

2. A method as in claim 1 wherein the tissue to be regenerated is liver tissue.

3. A method as in claim 1 wherein the granulocyte colony-stimulating factor is administered in an amount of mcg/kg of body weight/day for at least seven days.

4. A method for regenerating a human individual'"'"'s tissue comprising removing blood cells from the individual, controllably expanding the blood cells while maintaining their three-dimensional geometry and their cell-to-cell geometry, reintroducing the blood cells into the individual, determining the white blood cell content of the individual, administering granulocyte colony-stimulating factor to the individual while monitoring the white blood cell content of the individual, continuing the administration of the granulocyte colony-stimulating factor to the individual until the white blood cell content is more than twice its original amount, maintaining the administration of the granulocyte colony-stimulating factor to the individual at a level that maintains the white blood cell content at least at twice its original amount, monitoring the individual'"'"'s tissue to be regenerated, and discontinuing the administration of the granulocyte colony-stimulating factor to the individual when the tissue regenerates.

5. A method as in claim 4 wherein the tissue to be regenerated is liver tissue.

6. A method as in claim 4 wherein the granulocyte colony-stimulating factor is administered in an amount of 50 ng/kg of body weight/day for at least seven days.