Local production and/or delivery of anti-cancer agents by stromal cell precursors
First Claim
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1. A composition comprising a stromal cell precursor that is genetically modified to produce an anti-cancer agent.
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Abstract
The present invention concerns the use of compositions comprising, and methods for making, genetically modified mesenchymal stem cells to treat subjects with hyperproliferative disorders. Certain embodiments allow local delivery of an agent while avoiding systemic delivery of the agent alone. Stromat precursor cells may be used to produce a biological agent locally at tumor sites. The tumor microenvironment, or other proliferation inducing microenvironment, preferentially promotes the engraftment of stromal precursors as compared to other tissues.
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81 Claims
- 1. A composition comprising a stromal cell precursor that is genetically modified to produce an anti-cancer agent.
- 10. An anti-cancer composition comprising a stromal cell precursor engineered to express an anti-cancer gene product, wherein said stromal cell precursor preferentially localizes in an area of an organism undergoing hyperproliferative cell growth.
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20. A method for treatment of a subject with cancer comprising:
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a) isolating stromal cell precursors from a donor;
b) propagating the isolated stromal cell precursors in vitro;
c) genetically modifying one or more of the isolated stromal cell precursors to express a therapeutic agent; and
d) introducing genetically modified stromal cell precursors into said subject. - View Dependent Claims (21, 22, 23, 24, 25)
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- 26. A method for the delivery of a therapeutic agent to a patient comprising introducing a genetically modified stromal cell precursors to the patient.
- 33. A method for reducing tumor growth comprising administering genetically modified stromal cell precursors.
- 40. A method of reducing tumor burden in a patient with cancer comprising administering a genetically modified stromal cell precursors.
- 47. A method of treating metastatic cancer comprising administering a genetically modified stromal cell precursors.
- 54. A method of rendering an inoperable tumor operable comprising administering a genetically modified stromal cell precursors.
- 61. A method of increasing cancer patient survival comprising administering a genetically modified stromal cell precursors.
- 68. A method of inhibiting hyperproliferative disease comprising administering a genetically modified stromal cell precursors.
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75. A method of engrafling a therapeutic cell in a tumor comprising:
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a) isolating stromal cell precursors;
b) propagating the isolated stromal cell precursors in vitro;
c) genetically modifying one or more of the isolated stromal cell precursors to express a therapeutic agent; and
d) administering said genetically modified stromal cell precursors to a subject. - View Dependent Claims (76, 77, 78, 79, 80, 81)
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Specification