Methods and compositions for topical wound treatment

• US 20040076671A1
• Filed: 02/14/2003
• Published: 04/22/2004
• Est. Priority Date: 10/21/2002
• Status: Abandoned Application

• Current Assignee: Aletha Tippett
• Original Assignee: Aletha Tippett
• Inventors: Tippett, Aletha
• Application Number:
  US10/367,393
• Publication Number:
  US 20040076671A1
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/65 Tetracyclines
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00

Abstract

Compositions for improved treatment of wounds on a patient. A first composition having a safe and effective amount of lidocaine, wherein the composition is topically applied to a wound on a patient. A second composition having a safe and effective amount of lidocaine and a safe and effective amount of topical antibiotic, wherein the composition is topically applied to a wound on a patient. A method for treating a patient having a skin wound by locally administering a safe and effective amount of lidocaine and an antibiotic compound in the skin wound such that healing of the skin wound is enhanced.

Claims

1. A composition for use in the treatment of wounds, comprising a safe and effective amount of lidocaine in a carrier, wherein the composition is topically applied to a wound on a patient.

2. The composition of claim 1, wherein the lidocaine comprises viscous lidocaine.

3. The composition of claim 1, further comprising a safe and effective amount of a topical antibiotic compound.

4. The composition of claim 3, wherein the topical antibiotic comprises chloramphenicol, chlortetracycline, clindamycin, erythromycin, gramicidin, gentamicin, metronidazole, mupiroicin, neomycin, polymyxin B, bacitracin, silver sulfadiazine, tetracycline, chlortetracycline, or combinations thereof.

5. The composition of claim 3, wherein the topical antibiotic is polymyxin B sulfate.

6. The composition of claim 3, wherein the topical antibiotic is polymyxin B sulfate and bacitracin zinc.

7. The composition of claim 1, comprising from about 5 mg to about 40 mg lidocaine hydrochloride per gram of the composition.

8. The composition of claim 1, further comprising a wax matrix.

9. The composition of claim 8, wherein the wax matrix comprises Bag Balm®

.

10. The composition of claim 8, wherein the wax matrix comprises zinc oxide ointment.

11. The composition of claim 3, comprising from about 5 mg to about 40 mg lidocaine hydrochloride and about 250 units to about 2000 units polymyxin B sulfate and about 10 units to about 100 units bacitracin zinc per gram of the composition.

12. The composition of claim 1, further comprising oil of wintergreen.

13. The composition of claim 1, further comprising one or more enzymes for debridement.

14. A wound dressing comprising a bandage, a safe and effective amount of lidocaine in a carrier, wherein the wound dressing enhances healing of a wound.

15. The wound dressing of claim 14, wherein the bandage comprises cotton, gauze, fiberglass or synthetic material.

16. The wound dressing of claim 14, further comprising a safe and effective amount of a topical antibiotic compound.

17. The wound dressing of claim 14, further comprising saline.

18. The wound dressing of claim 14, further comprising a disinfectant component.

19. A method for treating a patient having a skin wound, comprising locally administering a safe and effective amount of lidocaine in a carrier to the skin wound such that the healing of the skin wound is enhanced.

20. The method of claim 19, further comprising locally administering a safe and effective amount of a topical antibiotic compound to the skin wound.

21. The method of claim 20, further comprising covering the lidocaine and antibiotic compound in the skin wound with a dressing.

22. The method of claim 21, wherein the dressing comprises cotton, gauze, fiberglass or synthetic material.

23. The method of claim 21, wherein the dressing comprises a polymeric film.

24. An article of manufacture comprising packaging material and a composition comprising a safe and effective amount of lidocaine in a carrier, wherein the packaging material comprises a label that indicates the composition is useful for treating a patient having a skin wound, and wherein local administration of the composition enhances healing of a skin wound.

25. The article of manufacture of claim 24, wherein the composition further comprises a safe and effective amount of a topical antibiotic compound.

26. A pre-packaged wound dressing contained in a package, comprising:

a safe and effective amount of lidocaine in a carrier;

a safe and effective amount of a topical antibiotic compound; and

a bandage configured to cover a wound.

27. The pre-packaged wound dressing of claim 26, wherein the lidocaine and the antibiotic compound are contained in a storage container.

28. The pre-packaged wound dressing of claim 26, wherein the bandage is coated on at least one side with the lidocaine and the antibiotic compound.

29. A method for treating a patient having a skin wound, comprising:

applying a zinc oxide ointment around the exterior of the wound;

applying lidocaine and an antibiotic compound to a dressing;

applying the dressing to the wound; and

securing the dressing to the patient.

30. The method of claim 29, further comprising placing a packing material containing lidocaine and an antibiotic compound directly in the wound.

31. The method of claim 29, wherein securing the dressing comprises placing a polymer film over the dressing and utilizing the zinc oxide ointment surrounding the exterior of the wound to secure the polymer film to the patient.

32. The method of claim 29, further comprising applying a saline solution to the dressing if the wound is dry.