Systems and methods for 3-D data acquisition for microwave imaging

• US 20040077943A1
• Filed: 04/04/2003
• Published: 04/22/2004
• Est. Priority Date: 04/05/2002
• Status: Abandoned Application

• Current Assignee: Keith D. Paulsen, Margaret W. Fanning, Paul M. Meaney, Timothy Reynolds
• Original Assignee: Keith D. Paulsen, Margaret W. Fanning, Paul M. Meaney, Timothy Reynolds
• Inventors: Reynolds, Timothy, Fanning, Margaret W., Paulsen, Keith D., Meaney, Paul M.
• Application Number:
  US10/407,886
• Publication Number:
  US 20040077943A1
• Time in Patent Office: Days
• US Class Current: 600/430
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves

Abstract

Tomographic imaging of biological tissue is achieved through a microwave imaging system and associated methods. An array of antennas are positioned in an illumination tank to surround biological tissue to be imaged. A liquid coupling medium is placed in the illumination tank, and the biological tissue is immersed in the medium. The array of antennas transmit and receive microwave-frequency RF signals that are propagated through the biological tissue. A signal processor is coupled to the antennas to process a demodulated signal representative of the microwave-frequency RF signal received by one or more of the antennas to produce scattered field magnitude and phase signal projections of the biological tissue. These projections may be used to reconstruct a conductivity and permittivity image across an imaged section of the biological tissue to identify the locations of different tissue types (e.g., normal versus malignant or cancerous) within the biological tissue. The liquid coupling medium may include glycerol in a solution with water or saline, or in an emulsion with water, and oil and an emulsifier. The liquid coupling medium containing glycerol provides a low-contrast medium that is beneficial when imaging low-permittivity objects, such as human breast tissue.

Claims

1. A low-contrast liquid coupling medium for microwave imaging of a sample, comprising:

a mixture of water and a polyol having three or more hydroxyl groups and 3 to 12 carbon atoms.

2. The liquid coupling medium of claim 1, the sample comprising biological tissue.

3. The liquid coupling medium of claim 1, the polyol comprising glycerol.

4. The liquid coupling medium of claim 3, wherein the mixture comprises a range from about 50 to 90 percent by volume of glycerol.

5. The liquid coupling-medium of claim 1, further comprising sodium chloride dissolved in the mixture.

6. The liquid coupling medium of claim 1, further comprising an emulsifier and an oil dissolved in the mixture.

7. In a microwave imaging apparatus having an illumination tank and an array of antennas, an improvement comprising:

seals integral with a base of the illumination tank through which the antennas slide into the illumination tank.

8. In a microwave imaging apparatus as in claim 7, a further improvement comprising:

a signal processor coupled to the antennas and configured for processing a demodulated signal representative of the microwave-frequency RF signal received by the one or more of the antennas, the signal processor being disposed outside of the illumination tank.

9. A system for imaging biological tissue with a microwave-frequency RF signal, comprising:

an illumination tank configured for accommodating the biological tissue, a plurality of bores formed into the tank, each bore having one or more seals formed therein;

a plurality of antennas extending through the bores and associated seals into the illumination tank, one or more of the plurality of antennas configured for receiving the microwave-frequency RF signal; and

a signal processor coupled to the receiving antennas and configured for processing a demodulated signal representative of the microwave-frequency RF signal received by the one or more of the plurality of antennas.

10. The system of claim 9, the signal processor comprising a plurality of receivers wherein each receiver is coupled to one of the receiving antennas and configured for generating the demodulated signal.

11. The system of claim 10, the signal processor comprising an A/D converter configured for generating a digital representation of the demodulated signal.

12. The system of claim 11, the signal processor coupled to one or more of the plurality of receivers and configured for comparing the phase and magnitude of the digital representations of the demodulated signal to that of a modulating waveform.

13. The system of claim 12, the signal processor further generating a visual representation of the conductivity and permittivity across the biological tissue from the comparison of the phase and magnitude of the digital representations of the demodulated signal to that of a modulating waveform.

14. The system of claim 9, the microwave-frequency RF signal having a frequency in a range of about 300 MHz to 3 GHz.

15. The system of claim 9, the demodulated signal comprising an intermediate frequency signal having a frequency in a range of about 1 KHz to 1 MHz.

16. The system of claim 9, the antennas being monopole antennas comprising:

a base region formed of a coaxial feed line having a center conductor, an insulator circumscribing the center conductor and a rigid outer conductor circumscribing the insulator;

a tip region extending out of the base and formed of the coaxial feed line without the rigid outer conductor; and

wherein the tip region extends to a first antenna end disposed within the illumination tank and the base region extends to a second antenna end disposed outside the illumination tank, the second antenna end having a connector formed therewith.

17. The system of claim 16, the connector configured for connection to a communications cable to carry signals between the signal processor and the monopole antennas.

18. The system of claim 9, further comprising an optical scanner for capturing optical image data of biological tissue disposed within the tank.

19. The system of claim 9, the plurality of bores being formed in a base of the illumination tank, the plurality of antennas extending along a longitudinal axis of the tank.

20. The system of claim 9, further comprising a transmitter configured for transmitting the microwave-frequency RF signal through one or more of the plurality of antennas such that the one or more antennas propagate the signal through the biological tissue.

21. The system of claim 20, wherein the plurality of antennas form a first array of antennas, and the transmission and reception of the microwave-frequency RF signal by the antennas is in a plane through the biological tissue transversely aligned with the illumination tank, the system further comprising a first actuator disposed outside of the illumination tank for adjusting the position of the first array of antennas within the illumination tank along a longitudinal axis of the tank, to select a particular transverse plane through the biological tissue.

22. The system of claim 21, further comprising a structural base onto which the illumination tank and the first actuator are positioned.

23. The system of claim 21, the first actuator comprising a computer-controlled linear actuator.

24. The system of claim 21, further comprising:

a mounting platform disposed outside of the illumination tank with which the first array of antennas are mounted; and

a drive shaft coupled to the mounting platform and selectively movable by the first actuator.

25. The system of claim 24, the first array of antennas having a threaded region for securing the antennas within a threaded bore of the mounting platform and a mounting flange disposed proximal to the threaded region for abutting the mounting platform.

26. The system of claim 20, the plurality of antennas forming a first array of antennas and a second array of antennas, the system further comprising one or more actuators disposed outside of the illumination tank, each actuator configured for adjusting the position of one of the first array of antennas and the second array of antennas within the illumination tank along a longitudinal axis of the tank, to selectively position the first array of antennas and the second array of antennas relative to one another;

wherein positioning of the first array of antennas and the second array of antennas provides three-dimensional data collection by one or more antennas of one of the first and second array of antennas detecting microwave signals transmitted by one or more antennas of the other of the first and second array of antennas, the first array of antennas and second array of antennas being positioned at differing transverse planes through the biological tissue.

27. The system of claim 26, wherein the one or more actuators includes a computer-controlled linear actuator.

28. The system of claim 26, further comprising:

a first mounting platform disposed outside of the illumination tank with which the first array of antennas are mounted;

a second mounting platform disposed outside of the illumination tank with which the second array of antennas are mounted; and

a drive shaft selectively movable by each actuator, each drive shaft coupled to one of the first mounting platform and the second mounting platform corresponding to the array of antennas movable by the actuator.

29. The system of claim 28, each antenna of the first array of antennas and the second array of antennas having a threaded region for securing the antenna within a threaded bore of the first mounting platform and the second mounting platform, respectively, and a mounting flange disposed proximal to the threaded region for abutting the respective mounting platform.

30. The system of claim 28, the first mounting platform having a plurality of bores formed therein and between the first array of antennas, the second mounting platform disposed at least partially beneath the first mounting platform to position the second array of antennas to extend through the bores to form the first array of antennas and second array of antennas in an interleaved, circular arrangement.

31. The system of claim 9, the seals comprising hydraulic seals.

32. The system of claim 9, the signal processor disposed outside of the illumination tank.

33. The system of claim 9, the illumination tank having a volume of a liquid coupling medium formed of a mixture of water and a polyol having three or more hydroxyl groups and 3 to 12 carbon atoms.

34. The system of claim 33, the polyol comprising glycerol, the mixture comprising a range from about 50 to 90 percent by volume of glycerol.

35. A system for imaging biological tissue with a microwave-frequency RF signal, comprising:

an illumination tank configured for accommodating the biological tissue, one or more bores formed into the tank and having one or more seals formed therein;

one or more drive shafts each extending through one bore and associated seals into the illumination tank;

one or more mounting platforms each mounted with the one or more drive shafts and disposed within the illumination tank;

a plurality of antennas mounted onto the one or more mounting platforms, one or more of the plurality of antennas configured for receiving the microwave-frequency RF signal; and

a signal processor coupled to the receiving antennas and configured for processing a demodulated signal representative of the microwave-frequency RF signal received by the one or more of the plurality of antennas.

36. The system of claim 35, the signal processor comprising a plurality of receivers wherein each receiver is coupled to one of the receiving antennas and configured for generating the demodulated signal.

37. The system of claim 36, the signal processor comprising an A/D converter configured for generating a digital representation of the demodulated signal.

38. The system of claim 37, the signal processor coupled to one or more of the plurality of receivers and configured for comparing the phase and magnitude of the digital representations of the demodulated signal to that of a modulating waveform.

39. The system of claim 38, the signal processor further generating a visual representation of the conductivity and permittivity across the biological tissue from the comparison of the phase and magnitude of the digital representations of the demodulated signal to that of a modulating waveform.

40. The system of claim 35, the microwave-frequency RF signal having a frequency in a range of about 300 MHz to 3 GHz.

41. The system of claim 35, the demodulated signal comprising an intermediate frequency signal having a frequency in a range of about 1 KHz to 1 MHz.

42. The system of claim 35, the antennas being monopole antennas comprising:

a base region formed of a coaxial feed line having a center conductor, an insulator circumscribing the center conductor and a rigid outer conductor circumscribing the insulator; and

a tip region extending out of the base and formed of the coaxial feed line without the rigid outer conductor;

wherein the tip region extends to a first antenna end disposed within the illumination tank and the base region extends to a second antenna end disposed outside the illumination tank, the second antenna end having a first connector formed therewith.

43. The system of claim 42, the first connector configured for connection to a communications cable to carry signals between the signal processor and the monopole antennas.

44. The system of claim 43, a cable bore formed through a wall of the illumination tank, the system further comprising:

a first communications cable section connected on a first end to the first connector and having a second connector formed on a second end of the cable section;

a coaxial connector bulkhead adapter having a first end connected to the second connector and a second end; and

a second communications cable section having a third connector formed at a first end and connected to the second end of the bulkhead adapter, the second communications cable extending to the signal processor.

45. The system of claim 35, further comprising a transmitter configured for transmitting the microwave-frequency RF signal through one or more of the plurality of antennas such that the one or more antennas propagate the signal through the biological tissue.

46. The system of claim 45, wherein the plurality of antennas form a first array of antennas mounted to one mounting platform mounted with one drive shaft, and the transmission and reception of the microwave-frequency RF signal by the antennas is in a plane through the biological tissue transversely aligned with the illumination tank, the system further comprising a first actuator disposed outside of the illumination tank for selectively moving the drive shaft along a longitudinal axis of the illumination tank to position the first array of antennas within the illumination tank to select a particular transverse plane through the biological tissue.

47. The system of claim 46, the first actuator comprising a computer-controlled linear actuator.

48. The system of claim 35, the first array of antennas having a threaded region for securing the antennas within a threaded bore of the first mounting platform and a mounting flange disposed proximal to the threaded region for abutting the mounting platform.

49. The system of claim 35, the plurality of antennas forming a first array of antennas mounted onto one mounting platform and a second array of antennas mounted onto another mounting platform, the system further comprising one or more actuators disposed outside of the illumination tank, each actuator configured for adjusting the position of one of the first array of antennas and the second array of antennas within the illumination tank along a longitudinal axis of the tank by moving the respective drive shafts, to selectively position the first array of antennas and the second array of antennas relative to one another;

wherein positioning of the first array of antennas and the second array of antennas provides three-dimensional data collection by one or more antennas of one of the first and second array of antennas detecting microwave signals transmitted by one or more antennas of the other of the first and second array of antennas, the first array of antennas and second array of antennas being positioned at differing transverse planes through the biological tissue.

50. The system of claim 49, wherein the one or more actuators includes a computer-controlled linear actuator.

51. The system of claim 49, each antenna of the first array of antennas and the second array of antennas having a threaded region for securing the antenna within a threaded bore of the respective mounting platform, and a mounting flange disposed proximal to the threaded region for abutting the respective mounting platform.

52. The system of claim 49, the mounting platform associated with the first array of antennas having a plurality of bores formed therein and between the first array of antennas, the mounting platform associated with the second array of antennas disposed at least partially beneath the first mounting platform to position the second array of antennas to extend through the bores to form the first array of antennas and second array of antennas in an interleaved, circular arrangement.

53. The system of claim 35, the one or more seals comprising hydraulic seals.

54. The system of claim 35, the signal processor disposed outside of the illumination tank.

55. The system of claim 35, the one or more bores formed in a base of the illumination tank, each drive shaft extending along a longitudinal axis of the tank.

56. The system of claim 35, the illumination tank having a volume of a liquid coupling medium formed of a mixture of water and a polyol having three or more hydroxyl groups and 3 to 12 carbon atoms.

57. The system of claim 56, the polyol comprising glycerol, the mixture comprising a range from about 50 to 90 percent by volume of glycerol.

58. A system for imaging biological tissue with a microwave-frequency RF signal, comprising:

an illumination tank configured for accommodating the biological tissue, one or more bores formed into the tank, each bore having one or more seals formed therein;

a support rod extending through each bore and associated seals into the illumination tank;

one or more antennas mounted with each support rod and disposed within the illumination tank; and

a signal processor coupled to the receiving antennas and configured for processing a demodulated signal representative of the microwave-frequency RF signal received by the one or more of the plurality of antennas.

59. The system of claim 58, further comprising a transmitter configured for transmitting the microwave-frequency RF signal through one or more of the antennas such that the one or more antennas propagate the signal through the biological tissue.

60. The system of claim 58, the one or more bores comprising a plurality of bores, the support rod extending through each bore forming a plurality of support rods, the system further comprising an actuator disposed outside of the illumination tank for adjusting the position of the plurality of support rods to selectively position the antennas along a longitudinal axis of the tank, to select a particular transverse imaging plane through the biological tissue.

61. The system of claim 60, each support rod mounted on a first end with a mounting platform disposed outside of the illumination tank and having one or more antennas mounted therewith on a second end, the mounting platform coupled to a drive shaft selectively movable by the actuator.

63. The system of claim 58, each antenna having a first connector formed therewith, the first connector configured for connection to a communications cable to carry signals between the signal processor and the antennas.

64. The system of claim 63, a cable bore formed through a wall of the illumination tank, the system further comprising:

a first communications cable section connected on a first end to the first connector and having a second connector formed on a second end of the cable section;

a coaxial connector bulkhead adapter having a first end connected to the second connector and a second end; and

a second communications cable section having a third connector formed at a first end and connected to the second end of the bulkhead adapter and extending to the signal processor.

65. The system of claim 58, the antennas comprising waveguide antennas.

66. A method of imaging biological tissue with a microwave-frequency RF signal, comprising the steps of:

positioning biological tissue within an illumination tank having a volume of a liquid coupling medium therein and having a plurality of antennas within the tank to surround the biological tissue;

generating a microwave-frequency RF signal;

transmitting the microwave-frequency RF signal through one or more of the plurality of antennas to propagate the signal through the biological tissue;

receiving the microwave-frequency RF signal propagated through the biological tissue; and

processing the received microwave-frequency RF signals to determine characteristics of the imaged biological tissue.

67. The method of claim 66, the steps of processing comprising:

generating a demodulated signal from the received microwave-frequency RF signal;

generating a digital representation of the demodulated signal;

comparing the phase and magnitude of the digital representations of the demoulated signals to that of a modulating waveform; and

reconstructing permittivity and conductivity images of the biological tissue using the phase and magnitude differences between the digital representation of the demodulated signal and the modulating waveform.

68. The method of claim 67, the demodulated signal comprising an intermediate frequency signal having a frequency in a range of about 1 KHz to 1 MHz.

69. The method of claim 68, further comprising:

optically scanning the biological tissue positioned within the illumination tank; and

generating a three-dimensional optical image of the biological tissue.

70. The method of claim 69, further comprising:

overlaying the conductivity and permittivity images with the three-dimensional optical image of the biological tissue to co-register features of the conductivity and permittivity images with the anatomy of the biological tissue.

71. The method of claim 66, the plurality of antennas forming a first array of antennas, the method further comprising displacing the first array of antennas along a longitudinal axis of the illumination tank for transmitting the microwave-frequency RF signal and receiving the microwave-frequency RF signal propagated through the biological tissue in selected transverse planes through the biological tissue.

72. The method of claim 66, the plurality of antennas forming a first array of antennas and a second array of antennas, the method further comprising displacing one or more of the first array of antennas and second array of antennas along a longitudinal axis of the illumination tank, and the step of transmitting the microwave-frequency RF signal comprises the transmission performed by one of the first array of antennas and the second array of antennas, and the step of receiving the microwave-frequency RF signal propagated through the biological tissue comprises the reception performed by the other of the first array of antennas and the second array of antennas, thereby facilitating detection of signals outside of a selected transverse plane of transmission defined by the transmitting array of antennas through the biological tissue.

73. The method of claim 72, the first array of antennas and the second array of antennas positioned in an interleaved, circular arrangement.

74. The method of claim 66, the liquid coupling medium comprising a mixture of water and a polyol having three or more hydroxyl groups and 3 to 12 carbon atoms.

75. The method of claim 74, the polyol comprising glycerol, the mixture comprising a volume of glycerol in a range from about 50 to 90 volume percent.

76. The method of claim 66, wherein the illumination tank has at least one sidewall and a base, the plurality of antennas extending into the illumination tank through seals integral with the base.

77. The method of claim 66, wherein the biological tissue is in vivo human breast tissue, the method being further for detecting malignant tissue.