System and method for monitoring blood glucose levels using an implantable medical device
First Claim
1. A method performed by an implantable medical device, the method comprising:
- detecting T-wave amplitude based on cardiac signals;
detecting QT interval based on cardiac signals; and
deriving a blood glucose level based on a combination of the detected T-wave amplitude and the detected QT interval.
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Abstract
T-wave amplitude and QT interval are derived from patient cardiac signals. Then blood glucose levels are determined based on a combination of the T-wave amplitude and the QT interval. By using a combination of both T-wave-based and QT interval-based signals, blood glucose levels can be reliably detected throughout a wide range of blood glucose levels. Once the blood glucose level has been detected, the implanted device compares the blood glucose level against upper and lower acceptable bounds and appropriate warning signals are generated if the level falls outside the bounds. In one example, wherein an implantable insulin pump is additionally provided, the pump is controlled based on the detected blood glucose level to maintain glucose levels within an acceptable range. A calibration technique is also provided for determining patient-specific parameters for use in the detection of blood glucose levels.
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Citations
25 Claims
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1. A method performed by an implantable medical device, the method comprising:
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detecting T-wave amplitude based on cardiac signals;
detecting QT interval based on cardiac signals; and
deriving a blood glucose level based on a combination of the detected T-wave amplitude and the detected QT interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable glucose monitor comprising:
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means for detecting cardiac signals;
means for detecting T-wave amplitude based on the cardiac signals;
means for detecting QT interval based on the cardiac signals; and
means for deriving blood glucose levels based on a combination of the detected T-wave amplitude and the detected QT interval.
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15. An implantable medical device comprising:
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a cardiac signal detection unit operative to detect T-waves and QT intervals; and
a glucose monitoring system operative to derive blood glucose levels based on a combination of the detected T-waves and the detected QT intervals. - View Dependent Claims (16, 17, 18)
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19. A method performed by an implantable medical device, the method comprising:
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detecting patient cardiac signals;
deriving a corrected QT interval from the cardiac signals; and
deriving blood glucose levels based on the corrected QT interval within at least a predetermined range of blood glucose levels. - View Dependent Claims (20)
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21. A method performed by an implantable medical device, the method comprising:
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detecting patient cardiac signals;
detecting a T-wave amplitude based on the cardiac signals;
detecting at least one additional feature of the cardiac signals wherein the at least one additional feature is known to exhibit a substantially monotonically-varying response as a function of blood glucose levels; and
deriving a blood glucose level based on a combination of the detected T-wave amplitude and the additional cardiac signal feature. - View Dependent Claims (22, 23, 24, 25)
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Specification