System and method for monitoring blood glucose levels using an implantable medical device
First Claim
1. A method performed by an external programmer device in communication with an implantable medical device implanted within a patient, the method comprising:
- receiving signals from the implantable device representative of electrical cardiac signals;
inputting signals representative of corresponding patient blood glucose levels;
determining parameters relating the electrical cardiac signals to the blood glucose levels for the particular patient; and
transmitting the parameters to the implantable device such that the implantable device can thereafter derive patient blood glucose levels from subsequently detected electrical cardiac signals.
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Accused Products
Abstract
T-wave amplitude and QT interval are derived from patient cardiac signals. Then blood glucose levels are determined based on a combination of the T-wave amplitude and the QT interval. By using a combination of both T-wave-based and QT interval-based signals, blood glucose levels can be reliably detected throughout a wide range of blood glucose levels. Once the blood glucose level has been detected, the implanted device compares the blood glucose level against upper and lower acceptable bounds and appropriate warning signals are generated if the level falls outside the bounds. In one example, wherein an implantable insulin pump is additionally provided, the pump is controlled based on the detected blood glucose level to maintain glucose levels within an acceptable range. A calibration technique is also provided for determining patient-specific parameters for use in the detection of blood glucose levels.
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Citations
19 Claims
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1. A method performed by an external programmer device in communication with an implantable medical device implanted within a patient, the method comprising:
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receiving signals from the implantable device representative of electrical cardiac signals;
inputting signals representative of corresponding patient blood glucose levels;
determining parameters relating the electrical cardiac signals to the blood glucose levels for the particular patient; and
transmitting the parameters to the implantable device such that the implantable device can thereafter derive patient blood glucose levels from subsequently detected electrical cardiac signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An external system for use with an implantable medical device implanted within a patient, the system comprising:
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means for receiving signals from the implantable device representative of electrical cardiac signals;
means for inputting signals representative of corresponding patient blood glucose levels;
means for determining parameters relating the electrical cardiac signals to the blood glucose levels for the particular patient;
and means for transmitting the parameters to the implantable device.
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15. An external system for use with an implantable medical device implanted within a patient, the system comprising:
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a calibration system operative to determine parameters relating electrical cardiac signals of the patient in which the device is implanted to blood glucose levels of the patient; and
a telemetry unit operative to transmit the parameters to the implantable device for use by the implantable device.
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16. A method performed in conjunction with an implantable medical device implanted within a patient, the method comprising:
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providing for an increase in blood glucose levels within the patient while detecting and recording electrical cardiac signals and patient blood glucose levels for a plurality of blood glucose levels;
decreasing the blood glucose levels while continuing to detect and record electrical cardiac signals and patient blood glucose levels for a plurality of blood glucose levels;
determining parameters relating the electrical cardiac signals to the patient blood glucose levels; and
using the parameters to derive blood glucose levels for the patient from subsequently detected electrical cardiac signals. - View Dependent Claims (17, 18, 19)
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Specification