Porous hydroxy apatite containing silicon and magnesium, and a preparation method thereof

• US 20040078087A1
• Filed: 08/26/2003
• Published: 04/22/2004
• Est. Priority Date: 08/30/2002
• Status: Active Grant

• Current Assignee: Korea Institute of Ceramic Engineering and Technology, META Blomed Company Limited
• Original Assignee: Korea Institute of Ceramic Engineering and Technology, META Blomed Company Limited
• Inventors: Kim, Hae-Jung, Kim, Young Hee, Lee, Yoon Joo, Song, Hee, Jung, Sang-Jin, Kim, Soo-Ryong
• Granted Patent: US 7,008,450 B2
• Time in Patent Office: Days
• US Class Current: 623/23.56
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2002/2807 Chin implants
• CPC Class Codes: A61F 2002/2878 for orbital repair
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00341 Coral, e.g. aragonite, porite
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges

Abstract

Disclosed are a silicon- and magnesium-containing porous hydroxyapatite, and a preparation method thereof which comprises the steps of performing a hydrothermal treatment of a natural coral and performing a solvothermal treatment.

Claims

1. A silicon- and magnesium-containing porous hydroxyapatite, having three-dimensionally connected pores in size of 200-500 μ

m, being similar to a human cancellous bone in structure, and comprising silicon and magnesium ions in an amount of 0.05-5 wt %, respectively.

2. A preparation method of a silicon- and magnesium-containing porous hydroxyapatite, comprising the steps of:

(1) performing a hydrothermal treatment of a coral sample pre-treated with a NaOCl solution in an aqueous (NH₄)₂HPO₄ solution; and

(2) performing a solvothermal treatment of the coral sample prepared in step (1) in a saturated solution of silicon acetate in acetone, to obtain the silicon- and magnesium-containing porous hydroxyapatite.

3. The preparation method according to claim 2, wherein contents of silicon and magnesium in the silicon- and magnesium-containing porous hydroxyapatite obtained in step (2) are respectively 0.05-5 wt %.

4. The preparation method according to claim 2, wherein the step (1) is performed at 150-300°

C. for 6-36 hours.

5. The preparation method according to claim 2, wherein the step (2) is performed at 100-250°

C. for 12-36 hours.

6. The preparation method according to claim 2, wherein the step (1) is repeatedly performed after completion of the step (2), to obtain a porous hydroxyapatite in single phase.

7. A silicon- and magnesium-containing porous hydroxyapatite used for an artificial bone including a spine or long bone, an orbital implant, or a chin implant, having three-dimensionally connected pores in size of 200-500 μ

m, being similar to a human cancellous bone in structure, and comprising silicon and magnesium ions in an amount of 0.05-5 wt %, respectively.