Methods of determining glucose concentration in whole blood samples
First Claim
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1. A method of determining glucose concentration in a whole blood sample comprising:
- providing an electrochemical sensor adapted to measure glucose and hematocrit concentrations;
measuring the hematocrit concentration of the whole blood sample using the electrochemical sensor via electrochemical impedance spectroscopy;
measuring the initial glucose concentration of the whole blood sample using the electrochemical sensor; and
calculating the unbiased glucose concentration in the whole blood sample using the initial glucose concentration measurement and the hematocrit concentration.
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Abstract
The glucose concentration in a whole blood sample may be determined by providing an electrochemical sensor adapted to measure glucose and hematocrit concentrations. The hematocrit concentration of the whole blood sample is measured using the electrochemical sensor via electrochemical impedance spectroscopy. The initial glucose concentration of the whole blood sample is measured using the electrochemical sensor. The unbiased glucose concentration in the whole blood sample is calculated using the initial glucose concentration measurement and the hematocrit concentration.
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28 Claims
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1. A method of determining glucose concentration in a whole blood sample comprising:
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providing an electrochemical sensor adapted to measure glucose and hematocrit concentrations;
measuring the hematocrit concentration of the whole blood sample using the electrochemical sensor via electrochemical impedance spectroscopy;
measuring the initial glucose concentration of the whole blood sample using the electrochemical sensor; and
calculating the unbiased glucose concentration in the whole blood sample using the initial glucose concentration measurement and the hematocrit concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of determining glucose concentration in a whole blood sample comprising:
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providing an electrochemical sensor adapted to measure glucose and hematocrit concentrations;
measuring the hematocrit concentration of the whole blood sample using the electrochemical sensor via electrochemical impedance spectroscopy using an amperometric monitoring system;
measuring the initial glucose concentration of the whole blood sample using the electrochemical sensor; and
calculating the unbiased glucose concentration in the whole blood sample using the initial glucose concentration measurement and the hematocrit concentration. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification