Biosensor having improved hematocrit and oxygen biases
First Claim
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1. A biosensor strip comprising:
- (a) an electrode support;
(b) a first electrode disposed on said electrode support, said first electrode being a working electrode, said working electrode comprising a working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme, a mediator, and at least one metal ion selected from the group consisting of a transition metal ion and heavier alkaline earth metal ion, wherein said mediator is 1,10-phenanthroline-5,6-dione or a derivative thereof;
(c) a second electrode disposed on said electrode support, said second electrode being a reference electrode; and
(d) a third electrode disposed on said electrode support, said third electrode being a counter electrode, said counter electrode comprising an electrically conductive material.
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Abstract
A biosensor that utilizes a mediator, i.e., an isomer of phenanthroline quinone, 1,10-phenanthroline-5,6-dione, and a metal ion, such as manganese, with an enzyme dependent upon NAD(P)+, such as, for example, glucose dehydrogenase, for improving the hematocrit bias and oxygen bias of biosensors. The electrodes of the biosensors employing this mediator and a metal ion provide an accurate clinical response over a hematocrit range that ranges from about 20% to about 70% and over an oxygen tension range that ranges from about 1 kPa to about 20 kPa.
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Citations
34 Claims
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1. A biosensor strip comprising:
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(a) an electrode support;
(b) a first electrode disposed on said electrode support, said first electrode being a working electrode, said working electrode comprising a working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme, a mediator, and at least one metal ion selected from the group consisting of a transition metal ion and heavier alkaline earth metal ion, wherein said mediator is 1,10-phenanthroline-5,6-dione or a derivative thereof;
(c) a second electrode disposed on said electrode support, said second electrode being a reference electrode; and
(d) a third electrode disposed on said electrode support, said third electrode being a counter electrode, said counter electrode comprising an electrically conductive material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A biosensor strip comprising:
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(a) an electrode support;
(b) a first electrode, said first electrode being a working electrode, said working electrode comprising working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme, a mediator, and at least one metal ion selected from the group consisting of a transition metal ion and heavier alkaline earth metal ion, wherein said mediator is 1,10-phenanthroline-5,6-dione or a derivative thereof. (c) a second electrode, said second electrode being a dualpurpose reference/counter electrode. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A biosensor strip comprising:
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(a) an electrode support;
(b) an electrode arrangement comprising at least two electrodes, one of said at least two electrodes being a working electrode, said working electrode disposed on said electrode support, said working electrode comprising a reaction layer comprising an enzyme, a mediator, and at least one metal ion selected from the group consisting of a transition metal ion and heavier alkaline earth metal ion, wherein said mediator is 1,10-phenanthroline5,6-dione or a derivative thereof;
(c) another of said at least two electrodes being a counter electrode, said counter electrode disposed on said electrode support. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A biosensor strip comprising:
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(a) an electrode support;
(b) an electrode arrangement comprising at least two electrodes, one of said at least two electrodes being a working electrode, said working electrode disposed on said electrode support, said working electrode comprising a reaction layer comprising an enzyme and a complex comprising a mediator and at least one metal ion selected from the group consisting of a transition metal ion and heavier alkaline earth metal ion, wherein said mediator is 1,10-phenanthroline-5,6-dione or a derivative thereof;
(c) another of said at least two electrodes being a counter electrode, said counter electrode disposed on said electrode support. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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Specification