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Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases

  • US 20040082521A1
  • Filed: 03/31/2003
  • Published: 04/29/2004
  • Est. Priority Date: 03/29/2002
  • Status: Abandoned Application
First Claim
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1. A method for the preparation of a variety of liposomal digitalis glycosides compositions for the use of treating cell-proliferative diseases in humans and mammals, the method comprising:

  • a) obtaining in a hydrophobic solvent a liposome forming mixture comprising a phosphalipid and cholesterol;

    b) adding a hydrophobic solution of digitalis glycoside to the mixture to form a drug;

    lipid ratio of about 1;

    10;

    c) hydrating the mixture with high speed mixing to form a suspension in aqueous solution;

    d) subjecting the suspension to high pressure microfluidization;

    e) evaporating the organic solvent under reduced pressure to form a lipid suspension in aqueous solution;

    f) filtering the suspension to remove any precipitated digitalis glycoside.

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