N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
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Abstract
The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.
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Citations
80 Claims
- 1. A compound of Formula (I):
- 7. A compound of Formula (II):
- 20. A compound of Formula (II-AA):
- 22. A compound of Formula (II-BB):
- 24. A comound of Formula (II-CC)
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26. A comound of Formula (II-DD)
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28. A comound of Formula (II-EE)
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29. A compound of Formula (II-FF)
- 30. A compound of Formula (II-GG):
- 32. A compound of Formula (II-HH):
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34. A compound of Formula (II-JJ):
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35. A compound selected from the group consisting of:
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36. A compound selected from the group consisting of:
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37. A compound of the following formula:
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38. A compound of the following formula:
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39. A compound of the following formula:
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40. A compound of the following formula:
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41. A compound selected from the group consisting of:
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1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;
1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;
3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(3-Chloro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;
(3-Fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine;
1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;
(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;
3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;
(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;
1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;
(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;
3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;
[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(3-Fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;
(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;
(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(2-Chloro-benzyl )-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;
(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;
(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-phenyl-amine;
3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-4-fluoro-phenyl)-amine;
(5-Chloro-2-methoxy-phenyl)-(2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-methoxy-phenyl)-amine;
(2,6-Dichloro-benzyl )-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
Butyric acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;
5-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-5-oxo-pentanoic acid methylamide;
1-[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-methoxy-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenol;
4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyric acid;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-3-pyrrolidin-1-yl-propane-1,3-dione;
N-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethyl-phenyl)-amine;
[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-methanol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3,5-dimethoxy-phenyl)-amine;
(3-Benzyloxy-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;
3-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-oxo-propionic acid ethyl ester;
3-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethyl-phenyl)-amine;
(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;
(3,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-hydroxy-ethanone;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-methoxy-phenyly-amine;
(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(2,5-dimethoxy-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-2-carboxylic acid 4-fluoro-phenyl ester;
3-[3-(3-Chloro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;
3-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(3,4-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[3-(3-Bromo-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propane-1,2-diol;
(2,5-Difluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethylsulfanyl-phenyl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(5-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-methoxy-phenyl)-amine;
(2,3-Dimethoxy-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-phenyl)-amine;
[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(1H-indol-5-yl)-amine;
(3-Chloro-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Chloro-4-fluoro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(3-Bromo-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;
Isobutyric acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-ethoxy-phenyl)-amine;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid ethyl ester;
(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(2,5-Difluoro-phenyl)-(6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-benzyl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Bromo-phenyl)-(6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Bromo-phenyl)-(6,7-diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-benzyl)-amine;
(1H-Indol-5-yl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-ethanone;
(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-trifluoromethyl-benzyl)-amine;
Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-ylmethyl ester;
(3-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
(4-Ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
3-[(6,7-Dimethoxy-3-phenylamino-4H-indeno[1,2-c]pyrazole-2-carbonyl)-amino]-propionic acid ethyl ester;
(2,5-Difluoro-phenyl)-(4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-2-yl-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
Benzyl-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-phenyl)-(5,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-amine;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(7-Benzyloxy-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6-Bromo-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
N3-Phenyl-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid 4-chloro-phenyl ester;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-benzyl)-amine;
3-[3-(2,6-Difluoro-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
(3-Methoxy-phenyl)-[6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine; and
[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(4-fluoro-phenyl)-amine.
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42. A compound selected from the group consisting of:
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(5-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethyl-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-methanol;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenol;
(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3,5-dimethoxy-phenyl)-amine;
(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Benzyloxy-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-methoxy-phenyl)-amine;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;
N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;
[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;
(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-a mine;
(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;
[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Difluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3,5-Dimethoxy-phenyl )-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3,4-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-ethyl-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-trifluoromethylsulfanyl-phenyl)-amine;
(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;
(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;
(3-Fluoro-phenyl )-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-4-fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(2-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-methoxy-phenyl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-methoxy-phenyl)-amine;
(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-4-fluoro-phenyl)-amine;
1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(2-Chloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(3-Chloro-4-methoxy-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,3-Dimethoxy-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(2,5-dimethoxy-phenyl)-amine;
(5-Chloro-2-methoxy-phenyl)-(2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
3-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(3-Fluoro-phenyl )-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-hydroxy-ethanone;
3-[3-(3-Chloro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-oxo-propionic acid ethyl ester;
1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;
4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyric acid;
Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
3-[3-(3-Bromo-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propane-1,2-diol;
Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
Butyric acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;
Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;
Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-ylmethyl ester;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-2-carboxylic acid 4-fluoro-phenyl ester;
5-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-5-oxo-pentanoic acid methylamide;
3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;
4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-3-pyrrolidin-1-yl-propane-1,3-dione;
(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
N-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide;
N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;
(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;
(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-amine;
(5-Bromo-pyridin-2-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;
(2,6-Dichloro-benzyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;
(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-phenyl-amine;
(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine; and
,3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol.
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43. A compound selected from the group consisting of:
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3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;
N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;
(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-amine;
(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;
(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;
(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;
(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;
(3-Fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(2-Chloro-benzyl )-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;
(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(3-Bromo-phenyl )-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;
[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;
1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(2-Chloro-benzyl )-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;
1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;
(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-amine;
(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;
3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;
3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;
3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-ethoxy-phenyl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
(3-Fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;
3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;
(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;
3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;
3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;
1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;
1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;
Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;
Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl methyl ester;
4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;
(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;
(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;
(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;
(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;
(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;
(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;
(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl )-phenyl-amine;
(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine; and
3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol.
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64. A method of identifying novel PDGF-R kinase inhibitors comprising the steps of:
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(a) determining a three-dimensional structure of the compound of Fomula I or II in the absence or presence of a polypeptide comprising the PDGF-R kinase catalytic domain;
(b) analyzing the three-dimensional structure for the compound alone or for the intermolecular interaction between said compound and PDGF-R;
(c) selecting a compound that mimics the structure for the compound alone or incorporates the predictive interaction;
(d) synthesizing said designed compound; and
(e) determining the ability of the molecule to bind and inhibit PDGF-R kinase activity.
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65. A method of identifying novel c-Abl kinase inhibitors comprising the steps of:
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(a) determining a three-dimensional structure of the compound of Fomula I or II in the absence or presence of a polypeptide comprising the c-Abl kinase catalytic domain;
(b) analyzing the three-dimensional structure for the compound alone or for the intermolecular interaction between said compound and c-Abl;
(c) selecting a compound that mimics the structure for the compound alone or incorporates the predictive interaction;
(d) synthesizing said designed compound; and
(e) determining the ability of the molecule to bind and inhibit c-Abl kinase activity.
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66. A method for reducing or inhibiting the PDGF-R kinase activity in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).
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67. A method for reducing or inhibiting the PDGF-R kinase activity in a subject coprising the step of administering to the subject a compound of Formula (I) or (II).
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68. A method for reducing or inhibiting the c-Abl kinase activity in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).
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69. A method for reducing or inhibiting the c-Abl kinase activity in a subject comprising the step of administering to the subject a compound of Formula (I) or (II).
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70. A method of inhibiting cell proliferation in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).
- 71. A process for the preparation of a compound of Formula (I):
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74. A process for the preparation of a compound of formula (S5)
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75. A process for the preparation of a compound of formula (S3)
- 76. A process for the preparation of a compound of Formula (IIa):
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79. A process for the preparation of a compound of formula (T5)
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80. A process for the preparation of a compound of formula (T3)
Specification