Novel salt forms of poorly soluble probucol esters and ethers
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Abstract
Organic amine salts of compounds of the formula:
and their pharmaceutically acceptable salts, and uses in medical therapy are provided.
18 Citations
94 Claims
- 1. A meglumine salt represented by the formula:
- 2. A meglumine salt represented by the formula:
- 8. A meglumine salt represented by the formula:
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15. A meglumine salt selected from the group consisting of:
butanedioic acid, mono [4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl]ester, meglumine salt;
acetic acid, [4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methyl-ethyl] thio]-2,6-bis(1,1-dimethylethyl)phenoxy]-, meglumine salt; and
butanoic acid, 4-[4-[[1-[[3,5-bis(1,1-dimethylethyl)4-hydroxyphenyl]thio]-1-methyl-ethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]-, meglumine salt.
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16. A pharmaceutical composition comprising a meglumine salt represented by the formula:
- 17. A pharmaceutical composition comprising a meglumine salt represented by the formula:
- 23. A pharmaceutical composition comprising a meglumine salt represented by the formula:
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30. A pharmaceutical composition comprising a compound of the formula:
- 31. A pharmaceutical composition comprising a compound of the formula:
- 37. A pharmaceutical composition comprising a compound of the formula:
- 60. An organic amine salt represented by the formula:
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61. An organic amine salt represented by the formula:
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62. An organic amine salt represented by the formula:
- 67. A pharmaceutical composition represented by the formula:
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68. A pharmaceutical composition represented by the formula:
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69. A pharmaceutical composition represented by the formula:
- 70. A compound of the formula:
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71. A compound of the formula:
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72. A compound of the formula:
Specification