Devices and methods for treating aortic valve stenosis
First Claim
1. A device for use in increasing the aortic valve area of a stenotic aortic valve, said device comprising:
- (a) a valve isolation element that includes;
(i) a ventricular side aortic valve occlusion element;
(ii) coronary ostia occlusion element; and
(iii) an ascending aorta occlusion element; and
(b) an aortic valve flushing element for flushing an isolated aortic valve with a dissolution fluid.
5 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods for their use in increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element and an aortic valve flushing element. The aortic valve isolation element is made up of a ventricular side aortic valve occlusion element, coronary ostia occlusion elements and an ascending aorta occlusion element. The aortic valve flushing element is made up of a dissolution fluid introducing element and a fluid removal element. In practicing the subject methods, a stenotic aortic valve is first isolated. Next, the isolated valve is flushed with a dissolution fluid, e.g., an acidic dissolution fluid, for a period of time sufficient for the aortic valve flow of the treated valve to be increased. In certain embodiments, the valve is also contacted with a dissolution fluid attenuating fluid, e.g., a buffer, during the flushing step in order to limit the contact of non-valve tissue with the dissolution fluid. Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.
138 Citations
42 Claims
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1. A device for use in increasing the aortic valve area of a stenotic aortic valve, said device comprising:
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(a) a valve isolation element that includes;
(i) a ventricular side aortic valve occlusion element;
(ii) coronary ostia occlusion element; and
(iii) an ascending aorta occlusion element; and
(b) an aortic valve flushing element for flushing an isolated aortic valve with a dissolution fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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15. A method of increasing the aortic valve area of a stenotic aortic valve, said method comprising:
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(a) isolating said stenotic aortic valve with a valve isolation element that includes;
(i) a ventricular side aortic valve occlusion element;
(ii) coronary ostia occlusion elements; and
(iii) an ascending aorta occlusion element; and
(b) flushing said isolated stenotic aortic valve with a stenosis dissolution fluid for a period of time sufficient to increase said stenotic aortic valve'"'"'s aortic valve area. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of at least reducing the amount of calcium mineral present on a calcified aortic valve, said method comprising:
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(a) isolating said calcified aortic valve with a valve isolation element that includes;
(i) a ventricular side aortic valve occlusion element;
(ii) coronary ostia occlusion elements; and
(iii) an ascending aorta occlusion element; and
(b) flushing said isolated calcified aortic valve with an acidic dissolution fluid for a period of time sufficient to at least reduce the amount of calcium mineral present on said calcified aortic valve. - View Dependent Claims (27, 28, 29, 30, 31)
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Specification