Method of controlling pharmacokinetics of immunomodulatory compounds
First Claim
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22. A method of administering an immunomodulatory substance comprising injecting or infusing the substance intradermally through one or more microneedles having a length and outlet suitable for selectively delivering the substance into the dermis to obtain absorption of the substance in the dermis.
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Abstract
A method and device for administration of an immunomodulatory substance into skin.
80 Citations
90 Claims
- 22. A method of administering an immunomodulatory substance comprising injecting or infusing the substance intradermally through one or more microneedles having a length and outlet suitable for selectively delivering the substance into the dermis to obtain absorption of the substance in the dermis.
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38-1. The method of claim 38 wherein said substance is a lipopolysacharride or BCG, or a synthetic derivative thereof.
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41. A method for delivering an immunomodulatory substance to a subject comprising:
- contacting the skin of the subject with a device having a dermal-access means for accurately targeting the dermal space of the subject with an efficacious amount of the bioactive substance.
- View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
- 55. A method for delivering an immunomodulatory substance into tissue comprising delivering the substance within or beneath the skin at least into the intradermal space to access one or more compartments, which compartments afford the substance different pharmacokinetics, which enhance the effectiveness of the substance in terms of a resultant composite pharmacokinetics.
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65-2. The method of claim 65 wherein the outlet is at a depth of about 750 μ
- m to about 1.5 mm when the needle is inserted.
Specification