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Method for manufacturing a tissue factor-based prothrombin time reagent

  • US 20040086953A1
  • Filed: 11/05/2002
  • Published: 05/06/2004
  • Est. Priority Date: 11/05/2002
  • Status: Active Grant
First Claim
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1. A method for manufacturing a tissue factor-based prothrombin time (PT) reagent, the method comprising:

  • combining predetermined quantities of tissue factor (TF), phospholipid and detergent-containing buffer to create a TF/phospholipid mixture, wherein the predetermined quantity of TF is based on a measured TF activity thereof; and

    removing the detergent from the TF/phospholipid mixture to create an essentially detergent-free TF/phospholipid vesicle mixture, thereby creating a tissue factor-based PT reagent.

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