Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

• US 20040087548A1
• Filed: 02/14/2002
• Published: 05/06/2004
• Est. Priority Date: 02/27/2001
• Status: Abandoned Application

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Sun, Chongping, Salvati, Mark E., Gottardis, Marco M., Attar, Ricardo M., Balog, James Aaron, Pickering, Dacia A., Martinez, Rogelio L.
• Application Number:
  US10/075,870
• Publication Number:
  US 20040087548A1
• Time in Patent Office: Days
• US Class Current: 514/81
• CPC Class Codes: A61K 31/403 condensed with carbocyclic rings, e.g. carbazole
• CPC Class Codes: A61K 31/407 condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 5/28 Antiandrogens
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Claims

1. A pharmaceutical composition capable of treating a NHR-associated condition, comprising a compound of the following formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier:

2. A method of modulating the function of a nuclear hormone receptor which comprises administering to a mammalian species in need thereof an effective nuclear hormone receptor modulating amount of a compound of the following formula I or a pharmaceutically acceptable salt thereof:

4. The method of claim 2, wherein said compound is selected from the group consisting of;

(3a α

,4α

,7aα

)-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(1H-tetrazol-5-yl)phenyl]-4, 7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1), (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-3-methyl-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1-methyl-2-oxo-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3a α

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-4-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,5-Dimethoxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2,3,5,6-Tetrafluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4, 7-methano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-indol-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4, 5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-2-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7aα

)-2-(4-Amino-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2,2′

-(2,3,5,6-Tetramethyl-1,4-phenylene)bis[3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione], (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,.(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(5-Chloro-2-hydroxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3, 4-trifluorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methoxybenzenecarboxylic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,5, 6-tetramethyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-Ethyl-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methyl-N-phenylbenzenesulfonamide, (3aα

,4α

,7α

,7aα

)-6-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2,4-dimethyl-3-pyridinecarbonitrile, (3aα

,4α

,7α

,7aα

)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2′

-hydroxy[1,1′

;

3′

,1″

-terphenyl]-5′

-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1, 4-benzodioxin-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-[2-Chloro-6-fluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα

,4α

,7α

,7aα

)-2-Fluoro-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[2-Ethoxy-8-methyl-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(9-Ethyl-9H-carbazol-2-yl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(1-piperidinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(4-morpholinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chlorophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1,2,3,4-tetrahydro-2-oxo-7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methylphenoxy]-2-methylpropanoic acid, ethyl ester, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(4-methyl-1-piperazinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-(Diethylamino)-1-naphthalenyl]-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1 ,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(1,2,3-thiadiazol-4-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-[2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-4-(trifluoromethyl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-N-[5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-3-(trifluoromethyl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-2-[3-Amino-5-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[1,2-Dihydro-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-[5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-6-(methylthio)-8-quinolinyl]acetamide, (3aα

,4α

,7α

,7aα

)-2-[5-Ethoxy-2-(methoxymethyl)-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[(1R)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[(1S)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-Fluoro-N-[3-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-5-(trifluoromethyl)phenyl]benzenesulfonamide, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[7-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[8-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethyl-5-isoxazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-( 1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα

,4α

,7α

,7aα

)-3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzo[b]thiophene-2-carboxylic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-nitro-8-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1), (3aα

,4α

,7α

,7aα

)-2-(4-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]acetamide, (3aα

,4α

,7α

,7aα

)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]methanesulfonamide, (3aα

,4α

,7α

,7aα

)-2-(5-Bromo-8-isoquinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(7,8-Dichloro-5-quinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]-N′

-methylurea, (3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methoxy-1-naphthalenecarbonitrile, (3aα

,4α

,7α

,7aα

)-2-(6-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(5-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-1H-indazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(6-Chloro-1H-indazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-nitro-1,2-benzisoxazol-3-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-benzofurancarboxylic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-2-(3-Benzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(5-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-iodophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,4-Benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,5-Dimethoxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2-Amino-4,5-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-1-Acetyl-6-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2,3-dihydro-1H-indole, (3aα

,4α

,7α

,7aα

)-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methylphenyl)-3a,4,7 ,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)-3a,4,7 ,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-2-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Amino-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Amino-2,3,5,6-tetramethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-6-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-1,4(2H,3H)-phthalazinedione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-5-nitro-2-pyridinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-Chloro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-a-phenylbenzeneacetonitrile, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methoxybenzoic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methylbenzonitrile, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-Ethyl-5-( 1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methyl-N-phenylbenzenesulfonamide, (3aα

,4α

,7α

,7aα

)-2,6-Dibromo-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)benzenesulfonamide, (3aα

,4α

,8α

,8aα

)-2-(2,3-Dimethyl-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2′

-hydroxy[1,1′

;

3′

,1″

-terphenyl]-5′

-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)hexahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-hydroxy-4,5-dimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-hydroxy-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-[2-Chloro-6-fluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-4-( 1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα

,4α

,7α

,7aα

)-5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-(4-morpholinyl)benzoic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-2-Fluoro-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,8α

,8aα

)-2-(9-Ethyl-9H-carbazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,8α

,8aα

)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-inden-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(5-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(6-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(5-isoquinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dinitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(2,5-Dibromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[2-Fluoro-5-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(2-Fluoro-5-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(2-Chloro-4-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[2-Chloro-5-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Fluorophenyl)tetrahydro-3,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Chlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3-iodophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Acetylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dimethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Ethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-iodophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[4-(1-methylethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzeneacetonitrile, (3aα

,4α

,7α

,7aα

)-2-(4-Ethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[4-[2-(Acetyloxy)ethyl]phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(4-propylphenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3a ,4α

,7α

,7aα

)-2-(4-Bromo-2,6-difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(6-Benzothiazolyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(1,3-Dihydro-3-oxo-5-isobenzofuranyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-N-[2-Nitro-4-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-2-(2-Ethyl-5-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2-methyl-5-benzofuranyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(1H-indazol-5-yl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-chlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[3-(trifluoromethoxy)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[2-(methylsulfonyl)-4-nitrophenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione;

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dibromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3-iodo-4-methylphenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-iodophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(2-methyl-6-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[2-(methylthio)-5-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-2,6-diethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-N-Methyl-3-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzamide, (3aα

,4α

,7α

,7aα

)-2-(6-Acetyl-1,3-benzodioxol-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-Bromo-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzoic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[5-[(Difluoromethyl)sulfonyl]-2-methoxyphenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[2-methyl-3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-(2,2-Difluoro-1,3-benzodioxol-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-[4-(4-Chlorophenoxy)-2-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-2-Fluoro-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-2-Chloro-4-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα

,4α

,7α

,7aα

)-N-[4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)phenyl]acetamide, (3aα

,4α

,7α

,7aα

)-2-[4-(1,1-Dimethylethyl)-3-nitrophenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-(3-methyl-4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[3-(1-methylethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-N-(1,1-Dimethylethyl)-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-1-naphthalenesulfonamide, (3aα

,4α

,7α

,7aα

)-2-[3-(1,1-Dimethylethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα

,4α

,7α

,7aα

)-N-Butyl-3-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzenesulfonamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,4-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-3-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-( 1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2,3-Dihydro-1H-inden-5-yl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-1-naphthalenecarbonitrile, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-1-naphthalenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Chloro-1-naphthalenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(5-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

, 6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(5-isoquinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dinitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2,4,5-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[2-Fluoro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5 aα

,6β

,6aα

)-2-(2-Fluoro-5-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2-Chloro-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[2-Chloro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,4-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Fluoro-4-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3,4,5-trichlorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]lisoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Acetylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,4-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(hydroxymethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzonitrile, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Fluoro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Chloro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitrophenyl)-4,6- ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(1-methylethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzeneacetonitrile, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-propylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2,3,4-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[4-(1,1-Dimethylethyl)-3-nitrphenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-2,6-difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(6-Benzothiazolyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-8-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Fluoro-3-methylphenyl)-4,4a,5 ,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-( 1,3-Dihydro-3-oxo-5-isobenzofuranyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-N-[2-Nitro-4-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)phenyl]acetamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(5-Acetyl-2-methyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2-Ethyl-5-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-5-benzofuranyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2,3-Dihydro-1-oxo-1H-inden-5-yl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(1H-indazol-5-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-3-chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5 ,5a,6,6a-Hexahydro-2-[3-(trifluoromethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-2-(trifluoromethyl)benzonitrile, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-methoxy-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dibromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodo-4-methylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-iodophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

, 6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Chloro-3-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-[(1-methylethyl)amino]-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-methyl-4-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[5-[(Difluoromethyl)sulfonyl]-2-methoxyphenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-[3-(1-methylethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-N-(1,1-Dimethylethyl)-5-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-1-naphthalenesulfonamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-[(trifluoromethyl)thio]phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-(2-methoxyphenoxy)-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-N-[4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-2-(trifluoromethyl)phenyl]acetamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Acetyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[3-(1,1-Dimethylethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-N-Butyl-3-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzenesulfonamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-methyl-3-(trifluoromethyl)phenyl]-4,6-A ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-Fluoro-5-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzonitrile, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-N-Methyl-3-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzamide, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, 2-(2-Fluorenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-[3-Chloro-4-(4-morpholinyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(2,3-Dihydro-1H-inden-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-1-naphthalenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-1-naphthalenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3-iodo-4-methylphenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(4-nitro-1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indol-5-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(5-quinolinyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indazol-6-yl)-1H-isoindole-1,3(2H)-dione, 2-(1,3-Benzodioxol-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Fluoro-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(8-quinolinyl)-1H-isoindole-1,3(2H)-dione, 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(5-isoquinolinyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trifluorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trichlorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,4,6-tetrafluorophenyl)-1H-isoindole-1,3(2H)-dione, 2-(3,4-Difluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 1-Acetyl-2,3-dihydro-6-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1H-indole, 2-(3-Chloro-4-fluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione 2-(3,4-Dichlorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3,4,5-trichlorophenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-methoxyphenyl)hexahydro-1-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methyl-1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3 ,4-Dimethylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-[4-Bromo-3-(trifiuorometlyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H )-dione, 2-(4-Fluoro-3-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2- [4-Fluoro-3-(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-3-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2- [4-Chloro-3-(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-2-methoxy-5-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Fluoro-4-methoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-Bromo-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoic acid, methyl ester, Hexahydro-2-(4-methyl-3-nitrophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3,4,5-trimethoxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-(3,4-Dimethoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[2-(2-pyridinyl)-1H-benzimidazol-5-yl]-1H-isoindole-1,3(2H)-dione, 2-(9-Ethyl-9H-carbazol-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methoxy-3-dibenzofuranyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,4-trifluorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-methyl-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[6-(methylthio)-5-nitro-8-quinolinyl]-1H-isoindole-1,3(2H)-dione, 2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(6-methyl-5-quinolinyl)-1H-isoindole-1,3(2H)-dione, N-(l,1-Dimethylethyl)-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1-naphthalenesulfonamide, Hexahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-1H-isoindole-1,3(2H)-dione, 2-(6-Benzothiazolyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-Methoxy-4-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoic acid, methyl ester, 2-Methyl-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzonitrile, Hexahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methyl-8-quinolinyl)-1H-isoindole-1,3(2H)-dione, 2- [3,5-Bis(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trimethylphenyl)-1H-isoindole-1,3(2H)-dione, 2-(4-Fluoro-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3-methoxy-4-methylphenyl)-1H-isoindole-1,3(2H)-dione, N-Ethyl-2-methyl-5-(octahydro-1 ,3-dioxo-2H-isoindol-2-yl)-N-phenylbenzenesulfonamide, 2-(2,3-Dimethyl-1H-indol-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Dibenzofuranyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(6-nitro-2-naphthalenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indazol-5-yl)-1H-isoindole-1,3(2H)-dione, 2-(4-Amino-2,3,5,6-tetrafluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-3-chlorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-1H-isoindole-1,3(2H)-dione, 4-(Octahydro-1,3-dioxo-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, Hexahydro-2-(9-oxo-9H-fluoren-1-yl)-1H-isoindole-1,3(2H)-dione, 2-Fluoro-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzonitrile, Hexahydro-2-(9-oxo-9H-fluoren-2-yl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-iodophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-2,3,5,6-tetrafluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1H-isoindole-1,3(2H)-dione, 2-(3-Bromo-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-2-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-2-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, (3aα

,4α

, 7α

,7aα

)-Hexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2-Amino-4,5-dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)hexahydro-4,7-methano-1,3(2H)-dione, (3 aα

,4α

,7α

,7 aα

)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-oxido-4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-oxido-6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(5-nitro-8-isoquinoliny)-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1), (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylsulfonyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylthio)phenyll-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylsulfinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-1-naphthalenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarboxylic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-2-(1,1-Dioxido-2H-naphth[1,8-cd]isothiazol-5-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-(6-hydroxy-3-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(1,2-Benzisothiazol-3-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3-Benzofuranyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-benzofurancarboxylic acid, methyl ester, (3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(4-isothiazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα

,4β

,7β

,7aα

)-3a,4,7,7a-tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-1lexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-2-(4-nitro-1 -naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(2-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5β

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1), (3aα

,4α

,5β

,7α

,7aα

)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5β

,7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5β

,7α

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,8β

,8aα

)-4,5,6,7,8,8a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-4,5,6,7,8,8a-Hexahydro-2-(4-nitrophenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-4,5,6,7,8,8a-Hexahydro-2-(2-naphthalenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-4,5,6,7 ,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-2-(3,4-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethanocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-4,5,6,7,8,8a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,8-ethanocyclohepta[c]pyrrole-1,3 (2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-2-(3,4-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4β

,8β

,8aα

)-2-(3,5-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-[4-(methylthio)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(5-chloro-2-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3 -methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(2,3-dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(3,4-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl)4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[2-methyl-5-(1-methylethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-N-(2-cyanophenyl)-1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dicarboximide, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(3-chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(2,3-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[3-(methylthio)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(4-fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(6-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(3-pyridinyl)-4,7-methano-1H-isoindole-1,3 (2H)-dione, 3 a,4,7,7a-Tetrahydro-2-(2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(3-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3 (2H)-dione, N-(4,6-Dimethyl-2-pyrmidinyl)-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-[4-(2-hydroxyethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(2-mercaptophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, 2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, methyl ester, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, 3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, methyl ester, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, N-(4,5-Dihydro-5-methyl-3-isoxazolyl)-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-(2-hydroxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[2-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-(phenylmethoxy)phenyll]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[2-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3 (2H)-dione, 3a,4,7 ,7a-Tetrahydro-2-[2- [(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(2-Chlorophenyl)methoxylphenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[(Benzoyloxy)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-(3,4-Dimethylbenzoyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, ethyl ester, 5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1,3-benzenedioic acid, 4-[2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)phenoxy]benzonitrile, 2-(5-Chloro-2-methoxyphenyl)-3a,4,7,7atetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(2-Acetylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-(5-oxazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-5-methyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2′

-[4-Bromo-3-(trifluoromethyl)phenyl]-3′

a,4′

,7′

,7′

a-tetrahydrospiro [cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione, (3aα

,4β

,4aα

6aα

,7β

,7aα

)-2-(4-Bromo-1 -naphthalenyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα

,4β

,4aα

,6aα

,7β

,7aα

)-2-(4-Bromo-3-methylphenyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα

,4β

,4aα

,6aα

,7β

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-8-(1-methylethylidene)-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(4-Bromo-1-naphthalenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-Hexahydro-8,8-dihydroxy-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4β

,7β

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-Tetrahydro-2-[[3-(trifluoromethyl)phenyl]amino]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-2-[(3-Chlorophenyl)amino]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-5-mercapto-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3a′

α

,4′

α

,7′

α

,7a′

α

)-2′

-(1,2-Dihydro-4-methyl-2-oxo-7-qiunolinyl)-3a′

,4′

,7′

,7a′

-tetrahydrospiro[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione, (3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-5-4-nitropheny)-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-mercaptophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, ethyl ester, 2-[4-(Diethylamino)phenyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,9,9a-Tetrahydro-2-phenyl-4,9[1′

,2′

]-benzeno-1H-benz[f]isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)-2-(4-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-(2-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)-2-(3-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, Octahydro-2-(4-methoxyphenyl)-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, 2-(2,4-Dichlorophenyl)octahydro-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, Octahydro-2-(4-nitrophenyl)-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, Hexahydro-5-hydroxy-2-(4-methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-hydroxy-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Chlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(2,4-Dichlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-Hydroxy-5-(octahydro-1,3-dioxo-5-phenyl-1H-isoindol-2-yl)benzoic acid, Hexahydro-2-(4-hydroxyphenyl)-5-phenyl-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-phenyl-1H-isoindole-1,3(2H)-dione, Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-diphenyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(4-methoxyphenyl)-5-methyl-1H-isoindole-1,3(2H)-dione, 5-(2,4-Dimethylphenyl)-1,6a-dihydro-1-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-d]-1,2,3-triazole-4,6(3aH,5H)-dione, Tetrahydro-2-phenyl-1H-isoindole-1,3,5(2H,4H)-trione, 5,6-Dibromo-2-(4-ethoxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5,6-dimethyl-2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5,6-dimethyl-2-(2-propoxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-2-methylphenyl)-3a,4,7,7a-tetrahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3′

a,4′

,7′

,7′

a-Tetrahydro-2′

-(2,4,6-trimethylphenyl)spiro[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione, 3a,4,7,7a-Tetrahydro-4-methyl-2-(3-methylphenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[4-(2-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-fluorophenyl)hexahydro-5-methyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 4-[1,3,3a,4,7,7a-Hexahydro-8-(1-methylethylidene)-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]benzonitrile, 3a,4,7,7a-Tetrahydro-2-(4-hydroxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-Methyl-2-propenoic acid, 4-(1,3,3a,4,7,7a-hexahydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)phenyl ester, 2-(4-Chlorophenyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione, 4-(1,3 ,3a,4,7,7a-Hexahydro-1,3-dioxo-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-phenyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(2-mercaptophenyl)-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-(methylthio)phenyl]-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione, 4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 3′

a,4′

,7′

,7′

a-Tetrahydro-2′

-(4-nitrophenyl)spiro[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione, 2-Hydroxy-5-(octahydro-1,3-dioxo-5-phenyl-4,7-methano-1H-isoindol-2-yl)benzoic acid, 4-(Octahydro-1,3-dioxo-5-phenyl-4,7-methano-1H-isoindol-2-yl)benzenesulfonamide, Hexahydro-2-(4-hydroxyphenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione and (3aα

,4α

,7α

,7aα

)-2-[4-nitro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione.

3. A method for treating a condition or disorder comprising administering to a mammalian species in need thereof a therapeutically effective amount of a compound of the following formula I or a pharmaceutically acceptable salt thereof: