Delivery composition and method
First Claim
Patent Images
1. A composition comprising:
- an emulsion comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises;
a membrane modulator; and
a wall forming material.
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Abstract
A composition which includes a membrane modulators is disclosed. The composition can be used in a wide range of therapies for delivering a membrane modulator which play an active function in regulating, controlling or causing a desired therapeutic effect to a target cell.
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Citations
65 Claims
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1. A composition comprising:
an emulsion comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises;
a membrane modulator; and
a wall forming material. - View Dependent Claims (2, 3, 4, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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5. A composition comprising:
a non-Newtonian fluid comprising a hydrophobic phase in contact with a hydrophilic phase, wherein the hydrophobic phase comprises;
a biologically active compound; and
a wall forming material. - View Dependent Claims (6, 7, 8)
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9. A composition comprising:
a non-Newtonian fluid comprising a hydrophobic phase in contact with a hydrophilic phase, wherein the hydrophobic phase comprises;
an amphiphile;
a biologically active compound; and
a wall forming material. - View Dependent Claims (10, 11)
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12. The composition of 9 wherein the amphiphile is a surfactant.
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13. A composition comprising:
a non-Newtonian fluid comprising a hydrophobic phase in contact with a hydrophilic phase, wherein the hydrophobic phase comprises;
a surfactant;
a sterol; and
a wall forming material. - View Dependent Claims (14)
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15. A composition comprising:
a non-Newtonian fluid comprising a hydrophobic phase in contact with a hydrophilic phase, wherein the hydrophobic phase comprises;
a surfactant;
a membrane modulator;
a wall forming material; and
an oil. - View Dependent Claims (16)
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17. A composition comprising:
a non-Newtonian fluid comprising a hydrophobic phase in contact with a hydrophilic phase, wherein the hydrophobic phase comprises;
a surfactant;
a membrane modulator; and
a charge source. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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46. The composition of 1 wherein the membrane modulator is a drug.
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47. A method of making a composition comprising liquefying a hydrophobic phase and mixing the hydrophobic phase with a hydrophilic phase to form a non-Newtonian fluid including a membrane modulator.
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48. The method of 47 wherein the liquefying comprises melting.
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49. The method of 47 wherein the mixing is accomplished using a high shear mixer.
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50. The method of 47 wherein the hydrophobic phase is liquefied to form a slurry.
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51. The method of 47 wherein the hydrophilic phase is added to the hydrophobic phase while mixing.
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52. The method of 47 wherein the hydrophobic phase is added to the hydrophilic phase while mixing.
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53. The method of 47 wherein the hydrophobic phase comprises:
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a membrane modulator; and
a wall forming material. - View Dependent Claims (56)
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- 54. The method of 53 wherein the membrane modulator is a animal sterol, plant sterol, antibiotic, amino acid, drug or peptide.
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57. A method of delivering a biologically active molecule comprising:
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providing a composition comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises a membrane modulator and a wall forming material; and
contacting the composition with a human body.
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58. The method of 57 wherein contacting includes transdermal delivery.
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59. The method of 57 wherein contacting includes intramuscular delivery.
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60. The method of 57 wherein contacting includes subcutaneous delivery.
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61. The method of 57 wherein contacting includes mucosal delivery.
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62. The method of 57 wherein contacting includes oral delivery.
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63. The method of 57 wherein contacting includes intravenous delivery.
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64. The method of 57 wherein contacting includes time release delivery.
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65. The method of 57 wherein contacting includes delivery through a needle having a 25 gauge or thinner bore needle.
Specification