Compositions and methods for enhancement of transdermal analyte flux
First Claim
1. A hydrogel composition for use in transdermal extraction of an analyte, said hydrogel composition comprising:
- a hydrophilic compound capable of forming a gel in the presence of water, an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and a pH of between about pH 6.5 to about pH 8.5.
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Abstract
The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
217 Citations
32 Claims
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1. A hydrogel composition for use in transdermal extraction of an analyte, said hydrogel composition comprising:
a hydrophilic compound capable of forming a gel in the presence of water, an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and a pH of between about pH 6.5 to about pH 8.5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 27, 28, 29, 30, 31, 32)
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22. A collection assembly/electrode assembly comprising,
a first hydrogel having first and second surfaces, said hydrogel comprising a hydrophilic compound capable of forming a gel in the presence of water, an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and a pH of between about pH 6.5 to about pH 8.5, and a first sensing electrode, wherein said first sensing electrode (i) is aligned to contact said second surface of said first hydrogel, and (ii) has a reactive surface comprising a platinum group metal and a polymer binder.
Specification