Non-invasive psychophysical measurement of glucose using photodynamics
First Claim
1. A method for determining the glucose concentration in blood comprising:
- (a) bleaching visual pigments in the retina of an observer'"'"'s eye with a bleaching light;
(b) conducting a psychophysical test that measures the observer'"'"'s psychophysical response to a visual stimulus;
(c) analyzing the psychophysical response to determine the rate of pigment regeneration; and
(d) analyzing the rate of pigment regeneration to determine the glucose concentration in the observer'"'"'s blood.
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Abstract
Blood glucose concentrations are measured by non-invasive methods and apparatus using visual pigment bleaching in conjunction with psychophysical methodologies. Bleaching light of selected wavelengths is projected through the pupil of the eye of an observer onto the fundus to bleach visual pigments in the eye. The observer'"'"'s psychophysical response to a visual stimulus is then measured to obtain information regarding the rate of regeneration of the visual pigments. From the rate of pigment regeneration, blood glucose concentrations are measured accurately. The psychophysical methodologies that may be used with the invention include visual acuity tests and color-matching tests.
145 Citations
22 Claims
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1. A method for determining the glucose concentration in blood comprising:
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(a) bleaching visual pigments in the retina of an observer'"'"'s eye with a bleaching light;
(b) conducting a psychophysical test that measures the observer'"'"'s psychophysical response to a visual stimulus;
(c) analyzing the psychophysical response to determine the rate of pigment regeneration; and
(d) analyzing the rate of pigment regeneration to determine the glucose concentration in the observer'"'"'s blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An apparatus for determining the concentration of glucose in blood comprising:
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(a) means for projecting a bleaching light into an eye of an observer to bleach visual pigments in the retina of the eye;
(b) means for providing a visual stimulus to the eye of the observer;
(c) means for analyzing the observer'"'"'s psychophysical response to the visual stimulus to determine the rate of pigment regeneration; and
(d) means for analyzing the rate of pigment regeneration to determine the concentration of glucose in the observer'"'"'s blood. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification