Solid solution perforator for drug delivery and other applications
First Claim
1. A system for controlled delivery of one or more drugs to a patient'"'"'s body, the system comprising:
- an array of one or more substantially solid drug solution delivery perforators, with each perforator having a first end with at least one point or blade adapted for penetrating skin and for providing a skin aperture on a patient'"'"'s body, with at least one of the perforators including a matrix material that is dissolvable, swellable or biodegradable within a selected time interval when the perforator is positioned within the patient'"'"'s body, and including a first selected drug distributed within the matrix, where the perforator array can be positioned adjacent to a selected region of the patient'"'"'s skin; and
an activatable pressure mechanism, associated with the at least one perforator, for causing the at least one perforator to penetrate the patient'"'"'s skin at the selected region, in response to activation of the pressure mechanism.
2 Assignments
0 Petitions
Accused Products
Abstract
A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient'"'"'s body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
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Citations
25 Claims
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1. A system for controlled delivery of one or more drugs to a patient'"'"'s body, the system comprising:
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an array of one or more substantially solid drug solution delivery perforators, with each perforator having a first end with at least one point or blade adapted for penetrating skin and for providing a skin aperture on a patient'"'"'s body, with at least one of the perforators including a matrix material that is dissolvable, swellable or biodegradable within a selected time interval when the perforator is positioned within the patient'"'"'s body, and including a first selected drug distributed within the matrix, where the perforator array can be positioned adjacent to a selected region of the patient'"'"'s skin; and
an activatable pressure mechanism, associated with the at least one perforator, for causing the at least one perforator to penetrate the patient'"'"'s skin at the selected region, in response to activation of the pressure mechanism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A system for diagnosis of a selected body fluid in a patient'"'"'s body, the system comprising:
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an array of one or more solid perforators, with each perforator having a first end with at least one point or blade adapted for penetrating skin and for providing a skin aperture on a patient'"'"'s body, with at least one of the perforators including a matrix material that is dissolvable, swellable or biodegradable within a selected time interval when the perforator is positioned within the patient'"'"'s body, where no drug is distributed within the matrix and where the perforator array can be positioned adjacent to a selected region of the patient'"'"'s skin; and
an activatable pressure mechanism, associated with the at least one perforator, for causing the at least one perforator to penetrate the patient'"'"'s skin at the selected region, in response to activation of the pressure mechanism.
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Specification