Cutaneous administration system
First Claim
1. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
- a jet dispenser comprising an orifice, and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and
a spacer positioned between the dispenser orifice and the target during ejection of the bioactive composition to the target.
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Accused Products
Abstract
Bioactive agents are cutaneously delivered by a jet dispenser using inkjet technology, such as that used in printing. The dispenser propels precise volumes of bioactive agent toward the skin, where they exert a local or topical effect, or move through the skin for transdermal systemic delivery. Drugs are either delivered directly to the skin, or are introduced into a transdermal patch, which may receive repeated dosages. A controller in the dispenser may control delivery of multiple different drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient, such as those monitored by a sensor in communication with the controller, for example to prevent an overdose. The dispenser may act as an electromechanical patch, capable of long term administration of drugs to the skin, to achieve local or systemic pharmaceutical effects. Administration methods are also provided, along with replacement kits.
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Citations
150 Claims
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1. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice, and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and
a spacer positioned between the dispenser orifice and the target during ejection of the bioactive composition to the target. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 101, 110, 111, 112, 113, 114, 115, 116, 117, 121, 122, 137, 138, 139, 142, 143, 144)
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55. A kit for filling an applicator having a jetting orifice with a bioactive composition for cutaneous delivery through ejection from said orifice to a subject, the kit comprising:
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a container which contains the bioactive substance, with the container having an interface to fluidically couple the container with the applicator to deliver said composition to the orifice; and
a dermal patch for placement on the subject to receive said composition from said orifice when spaced a selected distance therefrom. - View Dependent Claims (56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 145)
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80. A kit for administering a bioactive composition to a subject, the kit comprising:
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a jet dispenser comprising an orifice, and a container which delivers the bioactive composition to said orifice for ejection therethrough; and
a retainer for retaining the dispenser in contact with skin of a subject. - View Dependent Claims (81, 134, 135, 146, 147)
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82. A kit according to claim 82, further comprising a sensor which senses a physiological condition of the subject, and provides information about said condition to the controller.
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83. A method of administering a bioactive composition to a subject, the method comprising:
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applying to a cutaneous surface of the subject a jet dispenser comprising a container holding the bioactive composition;
dispensing the bioactive composition from the dispenser through at least one orifice toward the cutaneous surface; and
retaining the bioactive composition in prolonged contact with the cutaneous surface. - View Dependent Claims (84, 85, 86, 87, 88, 89, 90, 102, 103, 104, 108, 118, 119, 120, 123, 124, 125, 136, 140, 148, 149)
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91. A method of administering a bioactive composition to a subject, the method comprising:
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applying a cutaneous patch to skin of the subject; and
dispensing the bioactive composition from a jet dispenser by ejection through an orifice to the patch using inkjet technology. - View Dependent Claims (92, 93, 94, 95, 96, 97, 105, 106, 107, 109, 126, 127, 128, 129, 130, 131, 132, 133, 141, 150)
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- 98. A method according to 91 further comprising containing said bioactive composition a container portion of said jet dispenser prior to said dispensing.
Specification