Calcitonin drug-oligomer conjugates, and uses thereof
First Claim
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12. A calcitonin drug-oligomer conjugate comprising the structure of Formula I:
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Abstract
Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
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Citations
65 Claims
- 12. A calcitonin drug-oligomer conjugate comprising the structure of Formula I:
- 24. A calcitonin drug-oligomer conjugate comprising the structure of Formula II:
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34. A pharmaceutical composition comprising:
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a calcitonin drug coupled to an oligomer that comprises a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits; and
a pharmaceutically acceptable carrier. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method of treating a bone disorder in a subject in need of such treatment, said method comprising:
administering an effective amount of a calcitonin drug-oligomer conjugate comprising a calcitonin drug coupled to an oligomer that comprises a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits to the subject to treat the bone disorder. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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63-1. The method according to claim 62, wherein x is 9, y is 7, and z is 2.
Specification