Printing or dispensing a suspension such as three-dimensional printing of dosage forms
First Claim
1. A method of manufacturing a biomedical article, comprising:
- depositing a layer of powder;
dispensing, onto portions of the layer of powder, a suspension comprising solid particles of at least one substance selected from the group consisting of;
cells, cell fragments, cellular material, proteins, growth factors, bone particles, cartilage particles, other biological or inert materials which are insoluble or nearly insoluble, Active Pharmaceutical Ingredients, and very fine particles of the same material as the powder in the layer of powder;
and repeating the above steps as many times as needed to produce the biomedical article.
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Accused Products
Abstract
The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.
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Citations
16 Claims
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1. A method of manufacturing a biomedical article, comprising:
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depositing a layer of powder;
dispensing, onto portions of the layer of powder, a suspension comprising solid particles of at least one substance selected from the group consisting of;
cells, cell fragments, cellular material, proteins, growth factors, bone particles, cartilage particles, other biological or inert materials which are insoluble or nearly insoluble, Active Pharmaceutical Ingredients, and very fine particles of the same material as the powder in the layer of powder;
and repeating the above steps as many times as needed to produce the biomedical article. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A biomedical article comprising:
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a powder which is substantially insoluble;
a second substance selected from the group consisting of;
cells, cell fragments, cellular material, proteins, growth factors, bone particles, cartilage particles, other biological or inert materials which are insoluble or nearly insoluble, Active Pharmaceutical Ingredients, and very fine particles of the same material as the powder in the layer of powder. - View Dependent Claims (14, 15)
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- 13. A method of three-dimensional printing, comprising dispensing a suspension through a solenoid-operated valve onto powder.
Specification