Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
First Claim
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1. A controlled release therapeutic composition comprising a low solubility therapeutic agent, a structural polymer carrier and a solubilizing surfactant.
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Abstract
Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.
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Citations
29 Claims
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1. A controlled release therapeutic composition comprising a low solubility therapeutic agent, a structural polymer carrier and a solubilizing surfactant.
- 2. A controlled release therapeutic composition comprising a low solubility therapeutic agent, a structural polymer carrier and a solubilizing surfactant adapted to release a high dose of the therapeutic agent.
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15. A composition comprising a low solubility therapeutic agent, a structural polymer and a solubilizing surfactant adapted to release the therapeutic agent over a prolonged period of time.
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16. A composition comprising a low solubility therapeutic agent, a structural polymer and a solubilizing surfactant wherein the composition is a solid.
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17. A controlled release pharmaceutical composition comprising a low solubility therapeutic agent, a structural polymer and a solubilizing surfactant adapted to increase the solubility of the therapeutic agent.
- 18. A dosage form for controlled release of a therapeutic composition comprising a low solubility therapeutic agent, a structural polymer and a solubilizing surfactant.
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25. A controlled release oral dosage form for once-a-day administration of a therapeutic agent comprising:
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a. A core which comprises;
i. a low solubility therapeutic agent;
ii. a structural polymer;
iii. a solubilizing surfactant;
b. a semipermeable membrane surrounding the core; and
c. an exit orifice through the semipermeable membrane which communicates with the core so as to allow release of the therapeutic agent to the environment;
wherein the dosage form releases the therapeutic agent over a prolonged period of time. - View Dependent Claims (26, 27, 28, 29)
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Specification