Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
First Claim
1. A method of detecting disease based on the assessment of euchromatin, comprising identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in said first set of biological cells, and comparing said assessed variable to an expected value of said variable.
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Abstract
The present invention is a method of identifying and assessing DNA euchromatin in biological cells. The amount and/or distribution of DNA euchromatin generally relates to RNA/protein synthesis, which may change in certain conditions, such as disease, and/or cellular response to environmental and/or chemical agents. The present invention detects the potential presence of disease by assessing DNA euchromatin in ostensibly normal cells and similarly provides means to monitor and assess treatment response. The present invention may also be used to assess how application (or removal) of influences, such as environment, radiation, chemical agents, medications, herbs, vitamins, etc., interact to effect cells, establishing uses in monitoring wellness and pharmacological screening. Additional uses include assessing age related disorders, allergies, infections, Alzheimer'"'"'s disease, ‘Time of Death’, chronic fatigue syndrome, etc. The method may be advantageously applied to biological cells including micro-organisms, plants, animals, or cultured cells, alone or in conjunction with other markers.
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Citations
124 Claims
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1. A method of detecting disease based on the assessment of euchromatin, comprising
identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in said first set of biological cells, and comparing said assessed variable to an expected value of said variable.
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29. A method of assessing and monitoring wellness in a subject based on the assessment of euchromatin in biological cells, comprising
identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in said first set of biological cells, establishing a basal level of said variable, identifying euchromatin in a second set of biological cells, assessing said variable relating to said euchromatin in said second set of biological cells, and comparing said variable relating to said euchromatin in said second set of biological cells to said basal level.
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53. A method of assessing and monitoring wellness in a subject based on the assessment of euchromatin in biological cells, comprising
identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in said first set of biological cells, comparing said assessed variable to an expected value of said variable, identifying euchromatin in a second set of biological cells, assessing said variable relating to said euchromatin in said second set of biological cells, and comparing said variable relating to said euchromatin in said second set of biological cells to said expected value of said variable.
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77. A method of assessing response by a subject to exposure to an influence based on the assessment of euchromatin in biological cells, comprising
identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in first set of biological cells, establishing a basal level of said variable, exposing said subject to an influence, identifying euchromatin in a second set of biological cells, assessing said variable relating to said euchromatin in said second set of biological cells, and comparing said variable relating to said euchromatin in said second set of biological cells to said basal level.
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101. A method of assessing response by a subject to exposure to an influence based on the assessment of euchromatin in biological cells, comprising
identifying euchromatin in a first set of biological cells, assessing a variable relating to said euchromatin in said first set of biological cells, comparing said assessed variable to an expected value of said variable, exposing said subject to an influence, identifying euchromatin in said second set of biological cells, assessing said variable relating to said euchromatin in said second set of biological cells, and comparing said variable relating to said euchromatin in said second set of biological cells to said expected value of said variable.
Specification