OPHTHALMIC TREATMENT

• US 20040092548A1
• Filed: 06/07/1999
• Published: 05/13/2004
• Est. Priority Date: 12/21/1995
• Status: Abandoned Application

• Current Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Original Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Inventors: MARTINI, LUIGI, MALCOLMSON, RICHARD, EMBLETON, JONATHAN
• Application Number:
  US09/091,958
• Publication Number:
  US 20040092548A1
• Time in Patent Office: Days
• US Class Current: 514/310
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00

Abstract

The bioavailability of an ophthalmologically active compound is increased by its provision in a dosage of ophthalmic treatment liquid which takes the form of a jet or stream of droplets. Such a jet or stream can be directed or targeted at a particular site in the eye where the compound can be best absorbed.

Claims

1. A dosage form useful in ophthalmic treatment comprising a jet or stream of droplets of treatment fluid, each droplet having an ophthalmologically active compound in suspension or solution.

2. A dosage form according to claim 1 wherein the jet or each droplet has the active compound in aqueous suspension or solution.

3. A dosage form according to claim 1 or claim 2 wherein the jet or each droplet is of a size sufficient to sustain its momentum in transmission from a delivery device to a target site.

4. A dosage form according to claim 3 wherein the jet or each droplet is of a size sufficient to sustain momentum along a substantially horizontal path 5 cms in length from a discharge velocity of up to 25 m/sec from the delivery device.

5. A dosage form according to any preceding claim wherein the jet or each droplet has a diameter in the range 100 to 800 μ

m.

6. A dosage form according to claim 5 wherein the 3et or each droplet has a diameter in the range 200 to 400 μ

m.

7. A dosage form according to any preceding claim in which the total volume of treatment fluid does not exceed 10 μ

l.

8. A dosage form according to claim 7 in which the total volume of treatment fluid is in the range 3 to 8 μ

l.

9. A method of ophthalmic treatment comprising delivering to an eye a dosage form according to any preceding claim.

10. A method according to claim 9 wherein the eye is a human eye.

11. A method according to claim 9 or claim 10 wherein the dosage form is directed at a particular site in the eye.

12. A method of increasing the ocular bioavailability of ophthalmologically active compound, wherein the compound is provided in suspension or solution in a body of ophthalmic treatment liquid in a dosage form comprising the liquid as a jet and/or stream of droplets, the jet and/or droplets having a mean diameter in the range 20 μ

m to 1000 μ

m.

13. A method according to claim 12 wherein the mean diameter of the jet and/or droplets is in the range 100 μ

m to 800 μ

m, preferably 200 μ

m to 400 μ

m.

14. A method according to claim 12 or claim 13 wherein the total volume of treatment liquid in the dosage form does not exceed 10 μ

l.

15. A method according to claim 14 wherein the total volume of treatment liquid in the dosage form is in the range 3 μ

l to 8 μ

l.