×

Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds

  • US 20040092719A1
  • Filed: 09/11/2003
  • Published: 05/13/2004
  • Est. Priority Date: 09/17/2002
  • Status: Abandoned Application
First Claim
Patent Images

1. A method for separating IgG half antibodies from IgG whole antibodies, wherein the half antibodies and the whole antibodies are of the same isotype, comprising:

  • obtaining a sample that contains a mixture of IgG half antibodies and IgG whole antibodies of the same isotype;

    reducing the pH of the sample such that the half antibodies dissociate from one another to form a resulting solution; and

    applying the resulting solution to a column that differentially retards the mobility of the IgG half antibodies and IgG whole antibodies.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×