Bioactive components for incorporation with vaso-occlusive members

• US 20040093014A1
• Filed: 04/09/2003
• Published: 05/13/2004
• Est. Priority Date: 11/10/1998
• Status: Active Grant

• Current Assignee: Stryker European Operations Holdings, LLC (Stryker Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Eder, Joseph C., Wallace, Michael P., Ho, Hanh, Abrams, Robert M., Teoh, Clifford, Quan, Kenneth W. Jr., Slaikeu, Paul C., Barry, James
• Granted Patent: US 8,016,852 B2
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 65/04 Polyxylenes
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A vaso-occlusive device is disclosed. The device includes a vaso-occlusive member having a coating disposed thereon. In accordance with one embodiment, the coating comprises a polyacrylic material. In accordance with another embodiment, the coating comprises a polyvinyl alcohol-based material. In accordance with other embodiments, various other materials and coatings are applied to at least a portion of a vaso-occlusive device.

Claims

1. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a coating disposed on said vaso-occlusive member, said coating comprising a polyacrylic material.

2. The vaso-occlusive device of claim 1 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

3. The vaso-occlusive device of claim 2, wherein the coil is a cylindrical helical coil.

4. The vaso-occlusive device of claim 1, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

5. The vaso-occlusive device of claim 1, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

6. The vaso-occlusive device of claim 4, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

7. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a coating disposed on said vaso-occlusive member, said coating comprising a polyvinyl alcohol-based material.

8. The vaso-occlusive device of claim 7 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

9. The vaso-occlusive device of claim 8, wherein the coil is a cylindrical helical coil.

10. The vaso-occlusive device of claim 7, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

11. The vaso-occlusive device of claim 7, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

12. The vaso-occlusive device of claim 11, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

13. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material is a copolymer comprising polyglycolic acid and polycaprolactone.

14. The vaso-occlusive device of claim 13 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

15. The vaso-occlusive device of claim 14, wherein the coil is a cylindrical helical coil.

16. The vaso-occlusive device of claim 13, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

17. The vaso-occlusive device of claim 13, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

18. The vaso-occlusive device of claim 17, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

19. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material is a copolymer comprising polyglycolic acid, trimethylene carbonate, and polydioxanone.

20. The vaso-occlusive device of claim 19 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

21. The vaso-occlusive device of claim 20, wherein the coil is a cylindrical helical coil.

22. The vaso-occlusive device of claim 19, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

23. The vaso-occlusive device of claim 19, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

24. The vaso-occlusive device of claim 23, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

25. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material is a copolymer comprising polyglycolic acid and trimethylene carbonate.

26. The vaso-occlusive device of claim 25 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

27. The vaso-occlusive device of claim 26, wherein the coil is a cylindrical helical coil.

28. The vaso-occlusive device of claim 25, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

29. The vaso-occlusive device of claim 25, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

30. The vaso-occlusive device of claim 29, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

31. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material is a polymer material having a tantalum powder mixed therein.

32. A vaso-occlusive device, comprising:

a vaso-occlusive member;

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material comprises a silk material; and

a coating material that is applied to the vaso-occlusive device and that includes a silicone material.

33. The vaso-occlusive device of claim 32 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

34. The vaso-occlusive device of claim 33, wherein the coil is a cylindrical helical coil.

35. The vaso-occlusive device of claim 33, wherein the bioactive material is at least one fiber wound around the elongated helical coil.

36. The vaso-occlusive device of claim 35, wherein the elongated helical coil comprises a platinum material.

37. The vaso-occlusive device of claim 35, wherein the coating material is applied to said at least one fiber.

38. The vaso-occlusive device of claim 32, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

39. The vaso-occlusive device of claim 32, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

40. The vaso-occlusive device of claim 39, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

41. A vaso-occlusive device, comprising:

a vaso-occlusive member;

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material comprises a nylon material; and

a coating material that is applied to the vaso-occlusive device and that includes a silicone material.

42. The vaso-occlusive device of claim 41 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

43. The vaso-occlusive device of claim 42, wherein the coil is a cylindrical helical coil.

44. The vaso-occlusive device of claim 42, wherein the bioactive material is at least one fiber wound around the elongated helical coil.

45. The vaso-occlusive device of claim 44, wherein the elongated helical coil comprises a platinum material.

46. The vaso-occlusive device of claim 44, wherein the coating material is applied to the said at least one fiber.

47. The vaso-occlusive device of claim 41, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

48. The vaso-occlusive device of claim 41, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

49. The vaso-occlusive device of claim 48, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

50. A vaso-occlusive device, comprising:

a vaso-occlusive member;

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material comprises a polyethylene terephthalate material; and

a coating material that is applied to the vaso-occlusive device and that includes a silicone material.

51. The vaso-occlusive device of claim 50 wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

52. The vaso-occlusive device of claim 51, wherein the coil is a cylindrical helical coil.

53. The vaso-occlusive device of claim 51, wherein the bioactive material is at least one fiber wound around the elongated helical coil.

54. The vaso-occlusive device of claim 53, wherein the elongated helical coil comprises a platinum material.

55. The vaso-occlusive device of claim 53, wherein the coating material is applied to the said at least one fiber.

56. The vaso-occlusive device of claim 50, wherein the vaso-occlusive member comprises an occlusion subassembly that includes at least one lateral protrusion fixedly attached to a central member, said at least one lateral protrusion and the central member being of a size and overall flexibility to lodge at the neck portion of a vascular aneurysm.

57. The vaso-occlusive device of claim 50, wherein the vaso-occlusive member comprises a loop of wire having first and second ends connected to a base member.

58. The vaso-occlusive device of claim 57, further comprising a coil radially disposed about a portion of the loop of wire, the coating being further disposed on at least one portion of the coil.

59. A vaso-occlusive device, comprising:

a vaso-occlusive member; and

a bioactive material attached to said vaso-occlusive member, wherein the bioactive material attached to said vaso-occlusive member comprises at least one fiber having a silicone coating.

60. The vaso-occlusive device of claim 59, wherein said at least one fiber is a plurality of fibers, and wherein the vaso-occlusive device further comprises an attached coating that includes a silicone material.