Bioactive coatings to prevent tissue overgrowth on artificial heart valves
First Claim
1. A prosthetic heart valve resistant to tissue overgrowth following implantation of said prosthetic heart valve into a host, said heart valve comprising a sewing ring, and a housing component enclosing a valve component, wherein a member selected from said sewing ring, said housing component, said valve component and combinations thereof comprises at least one biologically active material in an amount sufficient to prevent tissue overgrowth.
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Abstract
The present invention provides a prosthetic heart valve that includes biologically active agents that retard or prevent the infiltration of fibrous tissue (“pannus”) from the host into the structure of the prosthetic valve. Preventing or decreasing the overgrowth of the prosthetic valve by pannus reduces the complications associated with the implantation and use of prosthetic heart valves.
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Citations
62 Claims
- 1. A prosthetic heart valve resistant to tissue overgrowth following implantation of said prosthetic heart valve into a host, said heart valve comprising a sewing ring, and a housing component enclosing a valve component, wherein a member selected from said sewing ring, said housing component, said valve component and combinations thereof comprises at least one biologically active material in an amount sufficient to prevent tissue overgrowth.
- 46. The heart valve according to claim 46, wherein said coating comprises a bioresorbable component.
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61. A method for preventing or reducing tissue overgrowth of a prosthetic heart valve following the implantation of said heart valve into a host, said method comprising:
prior to said implantation, incorporating into a component of said heart valve a biologically active agent in an amount sufficient to prevent or retard tissue overgrowth.
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62. A method of treating a patient requiring heart valve replacement, said method comprising:
replacing an existing valve with a prosthetic heart valve comprising a biologically active agent in an amount sufficient to prevent or retard tissue overgrowth.
Specification