Delivery of aerosols containing small particles through an inhalation route
First Claim
1. A method for preparing an aerosol of particles having a mass median aerodynamic diameter of less than 1 μ
- m comprising the steps of a) depositing a compound composition on a substrate b) heating said substrate to form a vapor of at least a portion of the composition c) mixing the resulting vapor with a gas, in a ratio to form an aerosol with a mass median aerodynamic diameter of less than 1 μ
m when a stable number concentration of particles in the gas is reached.
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Abstract
The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1μ for inhalation therapy. In an aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1μ. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200 nm, or 10 nm and 100 nm.
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Citations
17 Claims
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1. A method for preparing an aerosol of particles having a mass median aerodynamic diameter of less than 1 μ
- m comprising the steps of
a) depositing a compound composition on a substrate b) heating said substrate to form a vapor of at least a portion of the composition c) mixing the resulting vapor with a gas, in a ratio to form an aerosol with a mass median aerodynamic diameter of less than 1 μ
m when a stable number concentration of particles in the gas is reached. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- m comprising the steps of
Specification