System and method for detecting molecules using an active pixel sensor
First Claim
1. A system for testing a sample for the presence of target molecules, said system comprising:
- a first test site comprising probe molecules, said probe molecules being able to bind to said target molecules to form bound complexes;
a source system for providing incident electromagnetic radiation directed at said first test site, said incident electromagnetic radiation including radiation at a first wavelength; and
an active pixel sensor having a plurality of pixels, at least one of said pixels being disposed for detecting electromagnetic radiation from said test site.
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Abstract
In a molecule detection system and method, a sample containing target molecules is added to an array of test sites, with each test site containing distinct probe molecules. The probe molecules bind with the target molecules in the sample to form bound complexes. A source illuminates the array of test sites with incident electromagnetic radiation and an active pixel sensor detects the electromagnetic radiation from the array. To detect the presence of target molecules in the sample, the active pixel sensor detects changes in the optical properties of the test sites that result, either directly or indirectly, from their binding of the probe molecules with the target molecules. The target molecules may also be characterized on the basis of which probe molecules bind to them.
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Citations
16 Claims
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1. A system for testing a sample for the presence of target molecules, said system comprising:
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a first test site comprising probe molecules, said probe molecules being able to bind to said target molecules to form bound complexes;
a source system for providing incident electromagnetic radiation directed at said first test site, said incident electromagnetic radiation including radiation at a first wavelength; and
an active pixel sensor having a plurality of pixels, at least one of said pixels being disposed for detecting electromagnetic radiation from said test site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification