Composite stent with regioselective material and a method of forming the same

• US 20040098117A1
• Filed: 09/22/2003
• Published: 05/20/2004
• Est. Priority Date: 06/29/2001
• Status: Active Grant

• Current Assignee: Daryush Mirzaee, Orlando Padilla, Syed F.A. Hossainy
• Original Assignee: Daryush Mirzaee, Orlando Padilla, Syed F.A. Hossainy
• Inventors: Hossainy, Syed F.A., Mirzaee, Daryush, Padilla, Orlando
• Granted Patent: US 7,169,173 B2
• Time in Patent Office: Days
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10S 623/916 Blood vessel

Abstract

A composite stent and methods for making the same are provided. In one embodiment a regioselective band is formed in situ on the stent. In one embodiment, the band is made of a regioselective material having a high creep compliance and having a second modulus of elasticity lower than that of a structural material comprising the stent. In one embodiment, the regioselective material is drip-coated or dip-coated on the stent near the ends. In one embodiment, the regioselective material includes a therapeutic agent, which may be a radioactive emitter, an anti-platelet drug, or an anti-proliferative drug.

Claims

1. A stent comprising:

a regioselective band formed in situ on said stent.

2. The stent of claim 1 wherein said regioselective band covers a discrete region of said stent.

3. The stent of claim 2 wherein the discrete region of said stent is a region substantially adjacent to an end of the stent.

4. The stent of claim 1 wherein a material comprising said regioselective band is drip-coated onto a discrete region of said stent as said stent rotates.

5. The stent of claim 4 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

6. The stent of claim 4, in which said material has a high creep compliance and has a modulus of elasticity less than that of a second material comprising said stent.

7. The stent of claim 1 wherein a material comprising said regioselective band is dip-coated onto a discrete region of said stent as said stent rotates.

8. The stent of claim 7 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

9. The stent of claim 7, in which said material has a high creep compliance and has a modulus of elasticity less than that of a second material comprising said stent.

10. The stent of claim 1 wherein said regioselective band is a regioselective strip.

11. The stent of claim 10 wherein said regioselective strip is formed by slidably moving said stent as a material comprising said regioselective strip is drip-coated onto said stent.

12. The stent of claim 11 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

13. The stent of claim 10 wherein said regioselective strip is formed by slidably and rotatably moving said stent as a material comprising said regioselective strip is drip-coated onto said stent.

14. The stent of claim 13, in which said material has a high creep compliance and has a modulus of elasticity less than that of a second material comprising said stent.

15. The stent of claim 13 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

16. A composite stent comprising:

an expandable structural frame comprised of a first material having a first modulus of elasticity; and

an annular band disposed on a discrete region of the expandable structural frame, the band comprised of a regioselective material having a high creep compliance and having a second modulus of elasticity lower than the first material.

17. The composite stent of claim 16 wherein the discrete region is a region substantially adjacent to an end of the stent.

18. The stent of claim 16 wherein the regioselective material is drip-coated onto a discrete region of said stent as said stent rotates.

19. The stent of claim 18 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

20. The stent of claim 16 wherein the regioselective material is dip-coated onto a discrete region of said stent as said stent rotates.

21. The stent of claim 20 wherein said material includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

22. A method, comprising:

providing an expandable stent comprising a structural material having a first modulus of elasticity;

preparing a viscous solution comprising a regioselective material having a high creep compliance;

disposing the viscous solution on a discrete region of the stent;

moving the stent to form the viscous solution on the discrete region of the stent; and

curing the viscous solution in situ.

23. The method of claim 22 wherein the discrete region is a region substantially adjacent an end of the stent.

24. The method of claim 22 wherein said regioselective material has a second modulus of elasticity lower than the first modulus of elasticity.

25. The method of claim 24 wherein disposing the viscous solution comprises dripping the viscous solution onto the discrete region of the stent.

26. The method of claim 25 wherein the viscous solution includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.

27. The method of claim 25 wherein moving the stent comprises rotating the stent to form a band on the discrete region of the stent.

28. The method of claim 25 wherein moving the stent comprises sliding the stent to form a strip on the discrete region of the stent.

29. The method of claim 25 wherein moving the stent comprises rotating and sliding the stent to form a helical strip on the discrete portion of the stent.

30. The method of claim 24 wherein disposing the viscous solution comprises dipping the discrete region of the stent into the viscous solution.

31. The method of claim 30 wherein the viscous solution includes a therapeutic agent selected from the group consisting of a radioactive emitter, an anti-platelet drug, and an anti-proliferative drug.