Methods and compositions for treating hepatitis C virus
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Accused Products
Abstract
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
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Citations
129 Claims
- 1. A compound of Formula I:
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2. A compound of Formula II:
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3. A compound of Formula III:
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4. A compound of Formula IV:
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5. A compound of Formula V:
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6. A compound of Formula VI:
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7. A compound selected from Formulas VII, VIII and IX:
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8. A compound of Formulas X, XI and XII:
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9. A compound selected from Formulas XIII, XIV and XV:
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10. A compound of Formula XVI:
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11. A compound of Formula XVII:
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12. A compound of Formula XVIII:
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13. A compound of the structure:
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14. A compound of the structure:
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15. A compound of the structure:
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16. A compound of the structure:
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17. A compound of the structure:
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18. A compound of the structure:
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19. A compound of the structure:
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20. A compound of the structure:
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21. A compound of the structure:
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22. A compound of the structure:
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23. A compound of the structure:
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24. A compound of the structure:
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26. The compound as described in claim 187, wherein the dosage unit contains 10 to 1500 mg of said compound.
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27. The compound as described in claim 187 or 188, wherein said dosage unit is a tablet or capsule.
- 28. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula I:
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29. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula II:
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30. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula III:
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31. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula IV:
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32. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula V:
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33. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula VI:
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34. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formulas VII, VIII or IX:
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35. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula X, XI or XII:
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36. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XIII, XIV or XV:
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37. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVI:
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38. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVII:
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39. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVII:
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40. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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41. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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42. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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43. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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44. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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45. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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46. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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47. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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48. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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49. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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50. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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51. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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52. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula I:
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53. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula II:
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54. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula III:
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55. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula W:
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56. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula V:
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57. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula VI:
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58. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula VII, VIII or IX:
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59. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula X, XI or XII:
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60. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XIII, XIV or XV:
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61. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVI:
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62. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVII:
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63. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of Formula XVIII:
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64. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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65. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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66. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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67. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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68. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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69. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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70. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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71. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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72. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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73. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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74. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
- 75. A pharmaceutical composition for the treatment or prophylaxis of a Hepatitis C virus in a host, comprising an effective amount of a compound of structure:
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79. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula I:
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80. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula II:
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81. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula III:
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82. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula IV:
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83. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula V:
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84. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula VI:
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85. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula VII, VIII or IX:
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86. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula X, XI or XII:
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87. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XIII, XIV or XV:
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88. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVI:
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89. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVII:
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90. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVIII:
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91. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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92. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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93. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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94. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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95. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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96. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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97. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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98. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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99. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
- 100. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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101. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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102. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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103. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula I:
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105. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula III:
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106. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula IV:
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107. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula V:
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108. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula VI:
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109. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a, compound of Formula VII, VIII or IX:
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110. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula X, XI or XII:
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111. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XIII, XIV or XV:
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112. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVI:
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113. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVII:
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114. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an anti-virally effective amount of a compound of Formula XVIII:
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115. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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116. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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117. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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118. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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119. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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120. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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121. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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122. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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123. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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124. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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125. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
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126. A method for the treatment or prophylaxis of a Hepatitis C virus infection in a host, comprising administering an antivirally effective amount of a compound of the structure:
Specification