Diagnostic method for bacterial vaginosis based on detecting antibodies against gvh toxin of gardnerella vaginalis
First Claim
1. A method for the determination of the risk of pathologies in a population of women colonized by Gardnerella vaginalis bacterium, comprising the following steps in order:
- a) determination of the levels of IgA and/or IgG and/or IgM antibodies against the Gvh toxin secreted by G. vaginalis in a sample of body fluid;
b) comparison of said levels of IgA and/or IgG and/or IgM with prefixed levels of IgA and/or IgG and/or IgM, respectively;
c) determination of risk factor.
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Abstract
The current invention relates to a method for the determination of the risk of pathologies in a population of women colonized by the Gardnerella vaginalis bacterium, comprising the following steps in order:
a) determination of the IgA and/or IgG and/or IgM antibody levels against Gvh toxin secreted by G. vaginalis in a sample of body fluid;
b) comparison of said levels of IgA and/or IgG and/or IgM with predeterminate levels of IgA and/or IgG and/or IgM, respectively;
c) determination of the risk factor.
Said method resulted particularly efficient in permitting to obtain an accurate and reliable evaluation of the risk of pathologies related to the colonization by the bacterium G. vaginalis in women. Consequently, this method gives the physician an effective tool to decide whether or not to administer a pharmacological therapy.
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Citations
64 Claims
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1. A method for the determination of the risk of pathologies in a population of women colonized by Gardnerella vaginalis bacterium, comprising the following steps in order:
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a) determination of the levels of IgA and/or IgG and/or IgM antibodies against the Gvh toxin secreted by G. vaginalis in a sample of body fluid;
b) comparison of said levels of IgA and/or IgG and/or IgM with prefixed levels of IgA and/or IgG and/or IgM, respectively;
c) determination of risk factor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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Specification