Polymeric coatings containing a pH buffer agent

• US 20040102558A1
• Filed: 11/25/2002
• Published: 05/27/2004
• Est. Priority Date: 11/25/2002
• Status: Active Grant

• Current Assignee: AST Products Incorporated
• Original Assignee: AST Products Incorporated
• Inventors: Sheu, Min-Shyan, Lin, Tung-Liang, Loh, Ih-Houng
• Granted Patent: US 6,992,127 B2
• Time in Patent Office: Days
• US Class Current: 524/417
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08K 3/32 Phosphorus-containing compounds

Abstract

A device containing a support member, a cross-linked polymer, and a pH buffer agent. A surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded.

Claims

1. A kit comprising a pH buffer agent, a cross-linkable polymer, and a cross-linking compound for cross-linking the polymer.

2. The kit of claim 1, wherein the buffer agent includes inorganic salts.

3. The kit of claim 2, wherein the polymer is hydrophobic.

4. The kit of claim 2, wherein the polymer is water-based.

5. The kit of claim 4, wherein the polymer is hydrophobic.

6. The kit of claim 5, wherein the buffer agent includes potassium phosphate monobasic and sodium phosphate dibasic so as to maintain pH 6-6.8.

7. The kit of claim 2, wherein the polymer is polyurethane having carboxylate groups and the cross-linking compound is an aziridine, carbodiimide, or epoxy silane.

8. The kit of claim 2, wherein the buffer agent includes potassium phosphate monobasic and sodium phosphate dibasic so as to maintain pH 6-6.8.

9. The kit of claim 8, wherein the polymer is polyurethane having carboxylate groups and the cross-linking compound is an aziridine.

10. The kit of claim 1, further comprising a bioactive agent.

11. The kit of claim 10, wherein the bioactive agent is a bactericide.

12. The kit of claim 11, wherein the bactericide is silver chloride.

13. The kit of claim 10, wherein the bioactive agent is an anti-thrombogenic agent.

14. The kit of claim 13, wherein the anti-thrombogenic agent is heparin.

15. The kit of claim 1, wherein the polymer is hydrophobic.

16. The kit of claim 1, wherein the polymer is water-based.

17. The kit of claim 16, wherein the polymer is hydrophobic.

18. A device comprising:

a support member,

a cross-linked polymer, and

a pH buffer agent,

wherein a surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded.

19. The device of claim 18, wherein the buffer agent includes inorganic salts.

20. The device of claim 19, wherein the polymer is hydrophobic.

21. The device of claim 19, wherein the polymer is water-based.

22. The device of claim 21, wherein the polymer is hydrophobic.

23. The device of claim 22, wherein the buffer agent includes potassium phosphate monobasic and sodium phosphate dibasic so as to maintain pH 6-6.8.

24. The device of claim 23, wherein the polymer is polyurethane.

25. The device of claim 19, wherein the buffer agent includes potassium phosphate monobasic and sodium phosphate dibasic so as to maintain pH 6-6.8.

26. The device of claim 25, wherein the device is a medical device.

27. The device of claim 26, wherein the device is an implant device.

28. The device of claim 27, wherein the device is a urethral stent or heart valve.

29. The device of claim 18, further comprising a bioactive agent embedded in the cross-linked polymer.

30. The device of claim 29, wherein the bioactive agent is a bactericide.

31. The device of claim 30, wherein the bactericide is silver chloride.

32. The device of claim 29, wherein the bioactive agent is an anti-thrombogenic agent.

33. The device of claim 32, wherein the anti-thrombogenic agent is heparin.

34. The device of claim 18, wherein the polymer is hydrophobic.

35. The device of claim 18, wherein the polymer is water-based.

36. The device of claim 35, wherein the polymer is hydrophobic.

37. The device of claim 18, wherein the device is a medical device.

38. The device of claim 37, wherein the device is an implant device.