Device and method for adapting the size of an ion beam spot in the domain of tumor irradiation

• US 20040104354A1
• Filed: 07/11/2003
• Published: 06/03/2004
• Est. Priority Date: 11/21/2000
• Status: Active Grant

• Current Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Original Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Inventors: Ott, Wolfgang, Haberer, Thomas
• Granted Patent: US 6,859,741 B2
• Time in Patent Office: Days
• US Class Current: 250/396ML
• CPC Class Codes: A61N 2005/1074 Details of the control system, e.g. user interfaces
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention relates to an apparatus and to a method for adapting the size of an ion beam spot in tumour irradiation. For that purpose, the apparatus has a raster scanning device composed of raster scanning magnets (20) for raster scanning the ion beam (19). In addition, the apparatus comprises quadrupole magnets (10) determining the size of the ion beam spot, which quadrupole magnets (10) are arranged directly in front of the raster scanning magnets (20), and finally two magnet power supply units (18) for the quadrupole doublet of the quadrupole magnets (10) determining the size of the ion beam spot, the apparatus having a control loop for obtaining current correction values, by comparing desired and actual values of the prevailing dimension of the beam, for two magnet power supply units (18) of the quadrupole doublet arranged directly in front of the raster scanning magnets (20), for defined homogenization and/or for defined variation of the size of the ion beam spot.

Claims

1. Apparatus for adapting the size of an ion beam spot in tumour irradiation, comprising

a raster scanning device composed of raster scanning magnets (20) for raster scanning the ion beam (19),

characterised in that

quadrupole magnets (10) determining the size of the ion beam spot are arranged directly in front of the raster scanning magnets (20), and the apparatus has

two magnet power supply units (18) of the quadrupole doublet of the quadrupole magnets (10) determining the size of the ion beam spot, and

a control loop (21) that provides current correction values, by comparing desired and actual values of the prevailing beam count, for two magnet power supply units (18) of the quadrupole doublet arranged directly in front of the raster scanning magnets (20), and provides a defined homogenization and/or a defined variation of the size of the beam spot during beam extraction and/or from measuring cycle to measuring cycle and/or from beam position to beam position.

2. Apparatus according to claim 1, characterised in that the apparatus has real-time software for calculating the actual values of the ion beam width from raw detector data.

3. Apparatus according to either claim 1 or claim 2, characterised in that the apparatus has a position-sensitive detector (MWPC1) for detecting the ion beam width and for producing raw detector data.

4. Apparatus according to any one of claims 1 to 3, characterised in that the apparatus has control and read-out modules (SAM01 and SAMD) and associated data connections in order to send information on the actual value of ion beam widths to a storage, control and read-out module (SAMD) for storage of the measurement data.

5. Apparatus according to any one of claims 1 to 4, characterised in that one read-out module (SAMD) has a number of free interfaces and a computing capacity by means of which the tracking of the ion beam width can be performed.

6. Apparatus according to any one of claims 1 to 5, characterised in that the apparatus has a control system that is expanded by one control and read-out module, wherein exclusively the function of ion beam width regulation can be performed by the additional control and read-out module.

7. Apparatus according to any one of claims 1 to 6, characterised in that the apparatus has a control loop which starts from a multiwire ionization chamber (MWPC1) with attached control and read-out module (SAM01) and leads to a control and read-out module (SAMD) that provides measurement data for graphical representation and actuates two magnet power supply units (18) for horizontal and vertical focusing of the quadrupole doublet directly in front of the raster scanning magnets (20).

8. Method for adapting the size of an ion beam spot in tumour treatment, characterized by the method steps:

dynamic adaptation of the size of a beam spot in real time by

applying desired values for different ion beam sizes to the quadrupole magnet (10) determining the beam size between two successive accelerator cycles or within an acceleration cycle by means of adjustable frequency,

obtaining current correction values, by comparing desired and actual values of the prevailing dimension of the beam, for two magnet power supply units (18) of the quadrupole doublet of the quadrupole magnets (10) determining the size of the ion beam spot, for defined homogenization and/or for defined variation of the size of the ion beam spot during beam extraction and/or from measuring cycle to measuring cycle and/or from beam position to beam position,

irradiating tumour tissue (1) with a denser ion beam position raster and, at the same time, a smaller ion beam spot size in the edge region (3) than in the volume region (4) of the tumour.

9. Method according to claim 8, characterised in that the beam full width at half maximum is adapted to the ion beam position raster in such a way that, in the case of the fine ion beam position raster in the edge region (3), a smaller beam full width at half maximum is set than in the volume region (4) of the tumour with a coarse ion beam position pattern.

10. Method according to claim 8 or claim 9, characterised in that for every measuring cycle real-time software in a control and read-out module (SAM01) of a multiwire ionization chamber (MWPC1) calculates the actual value of the ion beam width from the raw detector data of the multiwire ionization chamber (MWPC1).

11. Method according to any one of claims 8 to 10, characterised in that information on the beam width is supplied to the module (SAMD) for storing the measurement data and for controlling and reading-out.

12. Method according to claim 11, characterised in that, in the module (SAMD) for storing, controlling and reading-out, the actual value of the ion beam spot size is compared in real time with the information on the desired value of the ion beam spot size from an irradiation plan.

13. Method according to any one of claims 8 to 12, characterised in that a correction value for magnet power supply units (18) of the quadrupole doublet of the quadrupole magnets (10) of a high-energy beam guide directly in front of the raster scanner, which quadrupole magnets (10) determine the size of the ion beam spot, is determined and set.

14. Method according to any one of claims 8 to 13, characterised in that a correction or resetting is performed from measuring cycle to measuring cycle of a position-measuring system or from one ion beam position in the irradiation plan to the next ion beam position.

15. Apparatus according to any one of claims 8 to 14, characterised in that setting of the frequency for tracking the ion beam width in the form of a parameter of real-time software that determines the correction values for the quadrupole doublet is carried out.

16. Method according to any one of claims 8 to 15, characterised in that tracking of the ion beam width is adjustably attenuated.

17. Method according to any one of claims 8 to 16, characterised in that threshold values for the ion beam width are established.