Apparatus and method for analysing fluids

• US 20040104736A1
• Filed: 02/02/2004
• Published: 06/03/2004
• Est. Priority Date: 03/13/2001
• Status: Abandoned Application

• Current Assignee: Hall Effect Technologies, Ltd.
• Original Assignee: Hall Effect Technologies, Ltd.
• Inventors: Djennati, Nasr-Eddine, Cohen, Emanuel
• Application Number:
  US10/471,504
• Publication Number:
  US 20040104736A1
• Time in Patent Office: Days
• US Class Current: 324/692
• CPC Class Codes: G01N 27/221 by investigating the dielectric properties using microwaves G01N22/00; measuring loss factors or dielectric constants per se G01R27/26
• CPC Class Codes: G01N 33/487 of liquid biological material

Abstract

Apparatus for analysing fluids, especially body fluids and blood, includes means for applying an oscillating electric field 1 to a sample of fluid and means for measuring electrical current flowing in the sample being analysed as a result of application of the applied field to enable the loss factor of an electrical circuit in which the sample is comprised to be determined. Changes in the loss factor with the frequency of field applied can be determined and by comparison with stored data, used to identify the presence and concentration of substances in a fluid. The apparatus may be arranged to analyse blood in a living body.

Claims

1. Apparatus for analysing body fluids in vivo, comprising:

an electrical oscillator electrically connected to electrode means adapted for wearing on a human or animal body, the electrical oscillator and electrode means being operative to apply an oscillating electric field to a body fluid, wherein the electrode means comprises two electrodes with each electrode being associated with an electrical insulator that serves to electrically insulate each electrode from the human or animal body on which the electrode means is worm,

means for measuring electrical current flowing in said body fluid as a result of the oscillating electric field to enable measurement of a loss factor and a power factor of an electrical circuit that includes the body fluid being analysed,

means for storing information,

means for comparing the measurement of said power factor of the body fluid being analysed with stored information in order to determine the presence and concentration of one or more substances in the body fluid; and

means to output information relating to an identified substance or substances to a user.

2. Apparatus as claimed in claim 1, wherein the body fluid is blood.

3. Apparatus as claimed in claim 1, wherein the electrodes comprise a clip.

4. Apparatus as claimed in claim 1, wherein the electrodes are comprised in a garment.

5. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to produce an oscillating electric field of variable frequency, and the means for measuring electrical current is operative to measure current when different field frequencies are being applied.

6. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to vary the frequency of an applied field through a range and the means for measuring electrical current is operative to measure current when different field frequencies are being applied.

7. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to vary the frequency of an applied field through a range extending from the order of kilohertz to the order of gigahertz.

8. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to vary the frequency of an applied field and said field is applied via the same electrodes, irrespective of frequency.

9. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to produce an oscillating electric field at one or more fixed frequencies.

10. Apparatus as claimed in claim 1, wherein the electrical oscillator is operative to produce an oscillating electric field at a single frequency, the frequency being suitable for determining the concentration of glucose in blood.

11. Apparatus as claimed in claim 1, wherein the two electrodes are arranged, in use, to be disposed on opposite sides respectively of a part of said human or animal body.

12. Apparatus as claimed in claim 1, wherein the apparatus controls an automated drug delivery system.

13. Apparatus as claimed in claim 1, wherein the electrodes each comprise a metallic coating on a thin ceramic disc.

14. Apparatus as claimed in claim 13, wherein the electrodes each comprise a metallic coating on a thin ceramic disc fixed to a ceramic annulus

15. A method of analysing body fluids, comprising the steps of:

(a) applying an oscillating electric field to a sample of fluid to be analysed by means of insulated electrodes,

(b) measuring electrical current flowing in the sample of fluid as a result of application of the oscillating electric field to enable a loss factor and a power factor of an electrical circuit in which the sample is comprised to be determined; and

(c) comparing the power factor measured with stored information to determine a presence and concentration of one or more substance in the sample of fluid.

16. A method as claimed in claim 15, wherein the sample of fluid is blood.

17. A method as claimed in claim 15, wherein the frequency of an applied field is varied through a range, and the power factor of a circuit in which the sample is comprised is calculated as the frequency is varied.

18. A method as claimed in claim 15, wherein the sample of fluid is analysed in vivo in a human or animal body.