Hemostatic wound dressings containing proteinaceous polymers

• US 20040106344A1
• Filed: 11/25/2003
• Published: 06/03/2004
• Est. Priority Date: 06/28/2002
• Status: Abandoned Application

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Zhang, Guanghui, Looney, Dwayne Lee
• Application Number:
  US10/721,836
• Publication Number:
  US 20040106344A1
• Time in Patent Office: Days
• US Class Current: 442/123
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: C08L 1/16 Esters of inorganic acids
• CPC Class Codes: C08L 1/24 Viscose
• CPC Class Codes: C08L 1/284 with hydroxylated hydrocarbon radicals
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: D04B 21/16 incorporating synthetic threads
• CPC Class Codes: D10B 2509/022 Wound dressings
• CPC Class Codes: D10B 2509/08 Hernia repair mesh
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

The present invention is directed to a hemostatic wound dressing that utilizes a fibrous, fabric substrate made from a biocompatible polymer suitable for use in the body and containing a first surface and a second surface opposing the first surface, the fabric having flexibility, strength and porosity effective for use as a hemostat; and further having a porous, polymeric matrix distributed on the first and second surfaces and through the fabric substrate, the porous, polymeric matrix being made of a biocompatible, water-soluble or water-swellable proteinaceous polymer.

Claims

1. A hemostatic wound dressing, comprising:

a fabric substrate, said fabric substrate comprising a first surface and a second surface opposing said first surface, said fabric comprising fibers and having properties effective for use as a hemostat, said fabric comprising a biocompatible polymer; and

a porous, polymeric matrix distributed on said first surface and said second surface and through said fabric substrate, said porous, polymeric matrix comprising a biocompatible, water-soluble or water-swellable proteinaceous polymer.

2. The wound dressing of claim 1 wherein said fabric comprises an oxidized polysaccharide.

3. The wound dressing of claim 2 wherein said oxidized polysaccharide comprises oxidized regenerated cellulose.

4. The wound dressing of claim 3 wherein said water-soluble or water-swellable proteinaceous polymer is selected from the group consisting of albumins, algal proteins, apoproteins, blood proteins, egg proteins, lectins, lipoproteins, metalloproteins, polyproteins, collagen, elastin, fibronectins, laminin, tenascin, vitronectin, fibroin, gelatin, keratin, reticulin, poly(alpha-amino acid), poly(beta-amino acid), poly(gamma-amino acid), polyimino acid and polypeptides.

5. The wound dressing of claim 4 wherein said proteinaceous polymer comprises non-cross-linked collagen.

6. The wound dressing of claim 1 wherein the weight ratio of said water-soluble or water-swellable proteinaceous polymer to said fabric is from about 1:

99 to about 20;

80.

7. The wound dressing of claim 5 wherein the weight ratio of said non-cross-linked collagen to said fabric is from about 3:

97 to about 10;

90.

8. The wound dressing of claim 3 wherein said oxidized regenerated cellulose comprises carboxylic-oxidized regenerated cellulose.

9. The wound dressing of claim 3 wherein said oxidized regenerated cellulose comprises aldehyde-oxidized regenerated cellulose.

10. The wound dressing of claim 1 further comprising a hemostatic agent.