Method of treating and preventing alzheimer disease through administration of delipidated protein and lipoprotein particles
First Claim
1. A composition effective to prevent or delay the onset of Alzheimer disease in a patient at risk of developing Alzheimer disease comprising one or more partially delipidated protein particles, one or more partially delipidated lipoprotein particles or a combination thereof.
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Abstract
The present invention relates to a method for preventing, reducing the progression of, and treating Alzheimer disease (AD), by creating delipidated protein particles and lipoprotein particles including at least one of LDL, VLDL, or HDL, other particles associated with lipid transport and metabolism, and combinations thereof, and administering these delipidated particles to patients at risk of developing AD or patients diagnosed with AD. The present invention employs energy and solvents useful for extracting lipids and cholesterol from the lipid-containing plasma and forming delipidated protein particles and lipoprotein particles. The present invention uses optimal solvent systems such that the lipid is dissolved while other plasma proteins are relatively intact. The present invention also provides a method of combining plasma delipidation and particle administration with other therapeutic interventions for prevention and treatment of AD.
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Citations
16 Claims
- 1. A composition effective to prevent or delay the onset of Alzheimer disease in a patient at risk of developing Alzheimer disease comprising one or more partially delipidated protein particles, one or more partially delipidated lipoprotein particles or a combination thereof.
- 2. A composition effective to treat Alzheimer disease in a patient with Alzheimer disease comprising one or more partially delipidated protein particles, one or more partially delipidated lipoprotein particles or a combination thereof.
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7. A method for treating Alzheimer disease in a patient diagnosed with Alzheimer disease comprising:
administration of an effective amount of one or more partially delipidated protein particles, one or more partially delipidated lipoprotein particles or a combination thereof, wherein the amount is effective to treat Alzheimer disease in the patient. - View Dependent Claims (9, 11, 13, 15)
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8. A method for preventing or delaying the onset of Alzheimer disease in a patient at risk of developing Alzheimer disease comprising:
administration of an effective amount of one or more partially delipidated protein particles, one or more partially delipidated lipoprotein particles or a combination thereof, wherein the amount is effective to prevent or delay the onset of Alzheimer disease in the patient. - View Dependent Claims (10, 12, 14, 16)
Specification